Abstract The two-faced reactivity of N-allenamides allows regio-and stereo-controlled functionalization on the a-, b- and γ-positions of the nitrogen atom. The contingency to obtain either proximal or distal adducts, makes those substrates essential for the construction of complex heterocyclic…
Abstract The progressive, neurodegenerative Alzheimer's disease (AD) is the most widespread dementia. Due to the ageing of the population and the current lack of molecules able to prevent or stop the disease, AD will be even more impactful for society in the future. AD is a multifactorial disease,…
Abstract Copper (Cu) in its ionic forms is an essential element for mammals and its homeostasis is tightly controlled. Accordingly, Cu-dyshomeostasis can be lethal as is the case in the well-established genetic Wilson's and Menkes diseases. In Alzheimer's disease (AD), Cu-accumulation occurs in…
Tweet The IFM team in collaboration with researchers at Institut Pasteur found that ions travel through lateral fenestrations in the extracellular domain of synaptic receptors to cross the post-synaptic membrane. This discovery contradicts the conventional textbook model of ion permeation at…
Abstract Miniaturized NMR (Nuclear Magnetic Resonance) devices are a trend in the industry because they allow a flexible use within a range of applications that would be otherwise not feasible with standard NMR equipment. However, one of the main obstacles in the development of miniaturized NMR…
The Institute of Chemistry is pleased to inform you that the LCQS team has recently contributed to a new article entitled “DFT exchange: sharing perspectives on the workhorse of quantum chemistry and materials science” published in Phys. Chem. Chem. Phys.: https://doi.org/10.1039/D2CP02827A Con…
Abstract Biphenol-based ligands have proven their ability to bind titanium(IV) centers and generate sophisticated self-assembled structures in which auxiliary nitrogen ligands often complete the coordination sphere of the metal and improve stability. Here, a central 4,4′-bipyridine, which acts as…
Abstract Gd5(L)16(H2O)8](Tf2N)15 was obtained from reaction of Gd2O3 with 1-carboxymethyl-3-ethylimidazolium chloride (LHCl). The material was found to be an ionic liquid that freezes to glassy state on cooling to −30 °C. Variable-temperature magnetic studies reveal the presence of weak magnetic…
Abstract Exploration of new organometallic systems based on polyhedral boron clusters has the potential to solve challenging chemical problems such as the stabilization of reactive intermediates and transition7 state-like species postulated for E−H (E = H, B, C, Si) bond activation reactions. We…
Abstract In this joint theoretical and experimental study, the analysis of weak interligand noncovalent interactions within Co(IV) [Cp*Co(phpy)X]+ cobaltacycles (phpy = 2-phenylenepyridine, κC,N) was carried out using the the Independent Gradient Model/Intrinsic Bond Strength Index (IGM/IBSI)…
Abstract During engine tests, it has been observed that the combined use of molybdenum dithiocarbamates (MoDTC) and methylene-bis(dithiocarbamates) (MBDTC) in formulated engine oils resulted in better fuel efficiency, keeping the friction coefficient stable at low values for a longer period of time…
Abstract A copper-catalysed three-component coupling reaction between a carbonyl derivative, a terminal ynamide and an amine has been developed for the one-pot green construction of γ-amino-ynamides from simple starting materials and with a broad functional group tolerance.The…
Abstract The presence of a permethylated α-cyclodextrin (α-CD) cavity in a chelating P,N ligand promotes exclusive formation of 1 : 1 ligand/metal complexes. In MX2 complexes, one of the two halido ligands is forced to reside inside the CD hollow while the second one is pointing outside. Unlike its…
Abstract Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to the disulfide GSSG. The cytosolic GSH/GSSG ratio is very high (>100), and its reduction can lead to…
Abstract Strigolactones (SLs) are plant hormones exuded in the rhizosphere with a signaling role for the development of arbuscular mycorrhizal (AM) fungi and as stimulants of seed germination of the parasitic weeds Orobanche, Phelipanche, and Striga, the most threatening weeds of major crops…
Abstract The preparation of several covalently linked [6]-helicene-porphyrins is reported. A fused [6]-helicene-porphyrin π-extended aromatic system was isolated, the enantiomers separated and the chiroptical properties determined. The oxidative cyclodehydrogenation proved to be very effective for…
Abstract The synthesis of natural products containing eight-membered heterocycles has proved to be highly challenging. In this contribution, an environmentally benign synthesis of benzo-1,5 dioxocines via ynamides is reported. A new class of ynamides was prepared by using a green and mild synthetic…
Abstract We report the first examples of metal-promoted double geminal activation of C(sp 3 )–H bonds of the N–CH 2 –N moiety in an imidazole-type heterocycle, leading to nickel and palladium NHC complexes under mild conditions. Reaction of the new electron-rich diphosphine 1,3-bis((di- tert…
Abstract A combined experimental/theoretical study of Ni pincer complexes with a bridgehead pyrimidine-based NHC and arylphosphino side arms revealed unique features about stepwise C–H activation, ethylene insertion into the Ni–H bond of an isolated complex followed by ethyl migration with C–CNHC…
