Abstract The development of copper-responsive magnetic resonance imaging (MRI) probes remains limited by the scarcity of robust strategies capable of operating under physiological conditions and within complex biological environments. Here we report CuII-responsive MRI contrast agents (CAs) which…
Abstract Quasi-optical experiments are emerging as a powerful technique to probe magnetic transitions in molecular spin systems. However, the simultaneous presence of the electric- and magnetic-dipole induced transitions poses the challenge of discriminating between these two contributions. In…
Abstract Over the past three decades, Single-Molecule Magnets (SMMs) have demonstrated consistently higher barriers for magnetization reversal (Ueff) and blocking temperatures (TB), exhibiting extremely slow magnetic relaxation at low temperatures. This and other associated phenomena, provided…
Abstract In the pursuit of CuII-responsive MRI contrast agents with enhanced CuII affinity, we report the synthesis and characterization of two LnIII-DO3A-C3AmpicGH complexes (LnIII = GdIII, EuIII), featuring a tetradentate CuII-binding moiety, along with the corresponding mononuclear CuII-C3AmpicG…
Abstract Imaging extracellular Cu2+ in vivo is important due to its role in physiological and pathological processes. Magnetic resonance imaging is a promising modality for this purpose but developing contrast agents selective for Cu2+ over abundant Zn2+ ions remains a challenge. We synthesized and…
Abstract Selective chemical modifications of biomolecules are in high demand for the development and implementation of chemical biology strategies. Methods involving radicals have emerged as powerful options yet potentially generate side reactivities when involving harsh reaction conditions. We…
Abstract Purpose of Review Although the biological mechanism of skin sensitization is a quite complex multi-stage process, the sensitization potency (or absence of potency) of a chemical is dependent on its chemical properties. Here we present an overview of the advances that have been made in our…
Abstract Dielectric and magnetoelectric (ME) studies were conducted on polycrystalline samples of the molecular spin triangle [Fe3O(O2CPh)6(py)3]ClO4·py (Fe3) and on its diamagnetic isostructural GaIII analogue (Ga3). Dielectric studies revealed a thermally activated process between approximately…
Abstract Electric fields represent an ideal means for controlling spins at the nanoscale and, more specifically, for manipulating protected degrees of freedom in multispin systems. Here we perform low-temperature magnetic far-IR spectroscopy on a molecular spin triangle (Fe3) and provide initial…
Absract Iron-copper complexes have been extensively studied in the search for efficient cytochrome c oxidase models. Whereas most dinuclear materials usually focus on fine-tuning the coordination of heme-Fe, this work shows that the coordination of copper in cytochrome c oxidase models should be…
Abstract The discovery of a stable organic radical formed under mild, clean, and efficient light-mediated conditions is reported. The structure of the stable acridinium-based radical photoproduct was unambiguously established by single-crystal X-ray diffraction, mass spectrometry, and in solution…
Abstract Imaging extracellular Cu2+ in vivo is of paramount interest due to its biological importance in both physiological and pathological states. Magnetic resonance imaging (MRI) is a powerful technique to do so. However, the development of efficient MRI contrast agents selective for Cu2+,…
Abstract The use of VIV and CuII spins to design weakly coupled and dissymmetric spin systems has been examined. Such systems were synthesized using porphyrin-based complexes, with external coordination sites allowing for the formation of dimers via a PdII linker ion. Continuous-wave (CW) Electron…
Abstract Several copper-ligands, including 1,10-phenanthroline (Phen), have been investigated for anticancer purposes based on their capacity to bind excess copper (Cu) in cancer tissues and form redox active complexes able to catalyse the formation of reactive oxygen species (ROS), ultimately…
Abstract Photoallergic contact dermatitis is a skin disease caused by combined exposure to photoreactive chemicals and sunlight. Exposure to allergens and the risk of skin sensitization is an essential regulatory issue within the industry. Yet, only few non-validated assays for photoallergy…
Graphical Abstract An asymmetric diradical was synthesized by grafting a nitroxide radical onto the [Y(Pc)2]⋅ radical system. The molecule was shown to exhibit a weak exchange interaction between its two radical units. The g-asymmetry combined with the magnetic interaction led to the electron…
Abstract Metal ion-catalysed overproduction of reactive oxygen species (ROS) are believed to contribute significantly to oxidative stress and be involved in several biological processes, from immune defence to development of diseases. Among the essential metal ions, copper is one of the most…
Graphical Abstract The diradical formed by functionalizing the yttrium(III)-phthalocyaninato radical with a nitroxide radical, is characterized by an engineered g-tensor asymmetry and a weak exchange coupling. Interestingly, its behavior is reminiscent of a spin qutrit, exhibiting two EPR…
Abstract Flavins and their alloxazine isomers are key chemical scaffolds for bioinspired electron transfer strategies. Their properties can be fine-tuned by functional groups, which must be introduced at an early stage of the synthesis as their aromatic ring is inert towards post-functionalization.…
Abstract Cu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone (CuII-Dp44mT) showed anticancer activity in the submicromolar concentration range in cell culture. The…
