Abstract The presence of a permethylated α-cyclodextrin (α-CD) cavity in a chelating P,N ligand promotes exclusive formation of 1 : 1 ligand/metal complexes. In MX2 complexes, one of the two halido ligands is forced to reside inside the CD hollow while the second one is pointing outside. Unlike its…
Abstract Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to the disulfide GSSG. The cytosolic GSH/GSSG ratio is very high (>100), and its reduction can lead to…
Abstract Strigolactones (SLs) are plant hormones exuded in the rhizosphere with a signaling role for the development of arbuscular mycorrhizal (AM) fungi and as stimulants of seed germination of the parasitic weeds Orobanche, Phelipanche, and Striga, the most threatening weeds of major crops…
Abstract The preparation of several covalently linked [6]-helicene-porphyrins is reported. A fused [6]-helicene-porphyrin π-extended aromatic system was isolated, the enantiomers separated and the chiroptical properties determined. The oxidative cyclodehydrogenation proved to be very effective for…
Abstract The synthesis of natural products containing eight-membered heterocycles has proved to be highly challenging. In this contribution, an environmentally benign synthesis of benzo-1,5 dioxocines via ynamides is reported. A new class of ynamides was prepared by using a green and mild synthetic…
Abstract We report the first examples of metal-promoted double geminal activation of C(sp 3 )–H bonds of the N–CH 2 –N moiety in an imidazole-type heterocycle, leading to nickel and palladium NHC complexes under mild conditions. Reaction of the new electron-rich diphosphine 1,3-bis((di- tert…
Abstract A combined experimental/theoretical study of Ni pincer complexes with a bridgehead pyrimidine-based NHC and arylphosphino side arms revealed unique features about stepwise C–H activation, ethylene insertion into the Ni–H bond of an isolated complex followed by ethyl migration with C–CNHC…
Abstract Citronellol, one of the most used fragrance compounds worldwide, is one ingredient of Fragrance Mix II used to assess skin allergy to fragrances in dermatitis patients. Pure citronellol is non-allergenic. Main issue is it autoxidizes when exposed to air becoming then allergenic. The…
Abstract IspG (also called GcpE) is an oxygen-sensitive [4Fe-4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated target for drug development. It converts 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate (MEcPP) into (E)-4-hydroxy-3-methyl-but-2-enyl-…
Abstract The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. The absence of this pathway in mammalians makes it an…
Abstract The first synthesis of gem-difluorinated ene–ynamides is presented via deprotonation of trifluoromethylated N-allenamides and δ extrusion of fluorine. These highly reactive building blocks, owing to their dual functional groups, offer a unique entry to difluorinated dienes and to…
Abstract A synthesis of new-to-nature aza-iridoids via ynamides is presented. ZrCl4 proved to be the best acid to perform this transformation. Various ynamides were accommodated, and seco-iridoids could be obtained as well. Aza-iridoids were infiltrated into leaves of Scrophularia Nodosa, an…
L'Institut de Chimie de Strasbourg a le plaisir de vous annoncer que l'article « Inorganic phosphate in growing calcium carbonate abalone shell suggests a shared mineral ancestral precursor » récemment publié dans Nature Communication, auquel Philippe Bertani (équipe Biophysique des membranes et RMN…
Abstract Combination of spin crossover metal ion and open-shell environment results in the mixing of high- and low- spin metal states, named as spinmerism.
Abstract Diaryl ditelluride derivatives bearing different functional groups were prepared with the aim to study their ability to interact through chalcogen bonding (ChB). Rectangular Te4 and triangular Te3 motifs were observed in the solid-state as a result of intermolecular Te⋅⋅⋅Te ChB. In…
Abstract N-Allenamides, substituted by an ester at the γ-position, were obtained through addition of terminal ynamides with ethyl diazoacetate under copper catalysis for the first time. Regio- and stereoselective hydroamination of those activated N-allenamides provided exclusively E-configured…
Abstract Quantum embedding is a divide and conquer strategy that aims at solving the electronic Schrödinger equation of sizeable molecules or extended systems. We establish in the present work a clearer and in-principle-exact connection between density matrix embedding theory (DMET) and…
Abstract A major research topic consists of revealing the contribution of radical-mediated reactions in dermatological diseases related to xenobiotic-induced stress to succeed risk-assessment procedures protecting producers and consumers. Allergic contact dermatitis is the clinically relevant…
Summary Chiral gold(I) acetylide trinuclear complexes 1 - 3 based on the cyclotribenzylene platform and terminal PR3 ligands (R = Ph, Et, and Cy, respectively), were characterized and their light emission studied. They exhibited long-lived blue phosphorescence in CHCl3 and a weak fluorescence in…
Abstract The theory developed in an accompanying paper [Déjardin, Phys. Rev. E105, 024109 (2022)] is used to compute the Kirkwood correlation factor of simple polar fluids of different nature. From this calculation, the theoretical static permittivity is readily obtained, which is compared with…
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