Organic & Biomolecular Chemistry

Abstract

An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described.  Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at room temperature. Likewise, terminal alkynes react with sulfonylamides to provide enesulfonamides. Z/E enesulfonamides can be transformed exclusively into E enesulfonamides.

Reference

Lucile Andna and Laurence Miesch
Metal-free synthesis of activated ynesulfonamides and tertiary enesulfonamides

The article was first published on 20 May 2019
Org. Biomol. Chem., 2019, Advance Article - DOI: https://doi.org/10.1039/C9OB00947G

Contact chercheur

Laurence Miesch, équipe SOPhy, Institut de Chimie, UMR 7177.