L’Institut de Chimie de Strasbourg est heureux de vous informer que l’équipe Ingénierie des Fonctions Moléculaires (UMR 7177, Institut de Chimie de Strasbourg) dirigée par Marco CECCHINI et l’équipe Signalisation et dynamique des récepteurs (UMR 3571, Institut Pasteur à Paris) dirigée par Pierre-Jean CORRINGER viennent d’obtenir un financement ANR pour leur projet commun GlyTrans.
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IFM Lab in collaboration with Pierre-Jean Corringer at Institut Pasteur (Paris) obtained funding at the ANR call 2025.
https://anr.fr/fileadmin/aap/2025/selection/aapg-2025-selection-vague2.pdf
(page 19)
Short description
The research project aims at constructing a microscopic kinetic model of synaptic receptor function with atomic resolution using an original combination of electrophysiology experiments and molecular dynamics simulations augmented by Markov-state modeling.
This research may open to pharma applications concerning with the modulation of by allosteric modulators and/or allosteric mutations as well as the characterization of potentially druggable intermediates. In addition, we would like to exploit generative AI technologies including Boltzmann generators and language models to accelerate Markov-state modeling construction. The research programme is funded for 4 years.
Contact
Marco Cecchini, équipe IFM, Institut de Chimie de Strasbourg (UMR 7177).
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