- Presentation
- Research Groups
- Biogéochimie moléculaire
- [BCB] Biométaux et Chimie Biologique
- [CLIC] Coordination, Ligands, Interactions et Catalyse
- [CBMB] Chimie et Biochimie de Molécules Bioactives
- [LCQS] Chimie Quantique de Strasbourg
- [LECPCS] Electrochimie et Chimie Physique du Corps Solide
- [COSyS] Catalyse Organométallique, Synthèse organique et Santé
- [SOPhy] Synthèse Organique & Phytochimie
- [LSAMM] Synthèse des Assemblages Moléculaires Multifonctionnels
- [LCSOM] Chimie et Systémique Organo-Métalliques
- [CBAT] Chimie Biologique et Applications Thérapeutiques
- [ECMC] Confinement Moléculaire et Catalyse
- [POMAM] Propriétés Optiques et Magnétiques des Architectures Moléculaires
- Biophysique des membranes et RMN
- [IFM] Laboratoire d’Ingénierie des Fonctions Moléculaires
- [SRCO] Synthèse, Réactivité et Catalyse Organométalliques
- [OMECA] Objets, MEtaux et CAtalyse
- [SOCAT] Synthèse Organométallique et CATalyse
- Scientific Services
- News
- Conferences
- CNRS and University directories
News
Org. Chem. Front. [SOPhy]
Abstract: A totally controlled regiodivergent azidation of activated N-allenamides is presented. Using TMSN3/TBAF, β-azidation of N-allenamides occurs exclusively, yielding vinyl azides. Conversely, employing a TFA/TMSN3 mixture results solely in the formation of γ-azides. A subsequent formal Winstein rearrangement of the latter with DBU produces α-amido vinyl azides. Additionally,...[more]
Nature Communications [IFM]
Tweet: The IFM team in collaboration with researchers at ENS Lyon and Institut Pasteur used advanced molecular simulations to investigate how cannabinoids bind to glycine receptors, an important pharmacological target for chronic pain. They discovered that tetrahydrocannabinol (THC) and anandamide (AEA) bind to more than one region of the receptor's transmembrane domain and characterized their...[more]
Prix de stage RJ- SCF-ALSACE: deux Lauréats pour l'UMR 7177
Félicitations à Fatih YILDIRIM et Titien SIMON, lauréats (première édition !) du prix de stage RJ- SCF-ALSACE (Réseau des Jeunes chimistes- Société Chimique de France - ALSACE). - Fatih YILDIRIM pour son stage de M1 (CHIMIE-PHYSIQUE INFORMATIQUE ANALYTIQUE & MATÉRIAUX, CPIAM) effectué au sein de l’Institut de Chimie de Strasbourg (UMR 7177), dans le Laboratoire de Chimie Quantique de...[more]
Angew Chem Int Ed [BCB/POMAM]
Abstract: Several copper-ligands, including 1,10-phenanthroline (Phen), have been investigated for anticancer purposes based on their capacity to bind excess copper (Cu) in cancer tissues and form redox active complexes able to catalyse the formation of reactive oxygen species (ROS), ultimately leading to oxidative stress and cell death. Glutathione (GSH) is a critical compound as it is highly...[more]
Nature Communications [ECMC]
Abstract: When aiming at the direct use of CO2 for the preparation of advanced/value-added materials, the synthesis of CO2/olefin copolymers is very appealing but challenging. The δ-lactone 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one (EVP), synthesized by telomerization of CO2 with 1,3-butadiene, is a promising monomer. However, its chemoselective ring-opening polymerization (ROP) is hampered...[more]
Chem. Eur. J. [COSyS]
Abstract: The aromatic Cope rearrangement is an elusive transformation that has been the subject of a limited number of investigations compared to those seemingly close analogues, namely the Cope and aromatic Claisen rearrangement. Herein we report our investigations inspired by moderate success observed in the course of pioneering works. By careful experimental and theoretical investigations,...[more]
Org. Lett. [COSyS]
Abstract An atom-economic and diazo-free strategy for the construction of novel pseudo anomeric C-1 alkenyl spirocyclopropyl sugars is described. Leveraging the 1,2-migration pathway of propargyl esters under gold(I) catalysis, easily available exo-glycals undergo β-selective alkenylcarbenoid insertion in moderate to excellent yields. Preferential activation of propargyl moieties and concerted...[more]