Abstract A seed recovered during archaeological excavations of a cave in the Judean desert was germinated, with radiocarbon analysis indicating an age of 993 CE– 1202 calCE. DNA sequencing and phylogenetic analysis identified the seedling as belonging to the angiosperm genus Commiphora Jacq.,…
Abstract Strigolactones exhibit dual functionality as regulators of plant architecture and signaling molecules in the rhizosphere. The important model crop rice exudes a blend of different strigolactones from its roots. Here, we identify the inaugural noncanonical strigolactone, 4-oxo-methyl…
Abstract Photoallergic contact dermatitis is a skin disease caused by combined exposure to photoreactive chemicals and sunlight. Exposure to allergens and the risk of skin sensitization is an essential regulatory issue within the industry. Yet, only few non-validated assays for photoallergy…
Abstract Organofluorines have a broad range of industrial applications, such as pharmaceutics, liquid crystal displays (LCD), solar cells, textiles, and construction coatings, and are used in peptidomimetics, surfactants, refrigerants, anesthetics, and agrochemicals. Among them are versatile…
Abstract A method for the construction of trifluorinated-5-methylenepyrrolidinone is reported. This strategy combines an acid-catalyzed two-carbon homologation process between ynamides and aldehydes, providing CF3-substituted dienes followed by a metal-free domino…
Graphical Abstract An asymmetric diradical was synthesized by grafting a nitroxide radical onto the [Y(Pc)2]⋅ radical system. The molecule was shown to exhibit a weak exchange interaction between its two radical units. The g-asymmetry combined with the magnetic interaction led to the electron…
Abstract The controlled growth of self-assembled networks on surfaces based on viologen salts is a major scientific challenge due to their unique electronic properties. The combination of solid-state NMR spectroscopy and atomic force microscopy at ambient conditions can unravel the fine…
Abstract This work merges two different types of many-electron ensembles, namely, the Theophilou-Gross-Oliveira-Kohn ensembles of ground and neutrally excited states, and the more recent ð‘-centered ensembles of neutral and charged ground states. On that basis, an in-principle exact and general,…
Summary Rigid terdentate ‘pincer' ligands containing a bridgehead N-heterocyclic carbene (NHC) donor attract considerable interest as spectators in transition metal complexes with broad scope and potential applications in the fields of catalysis, medicinal chemistry and material science. This…
Summary Pyridine Ring-Expanded dicarbene Pincer ligands were synthesized and some representative complexes with Ni and Cr show distinct geometrical and electronic characteristics from analogues with 5-membered ring heterocycles, opening new possibilities for pincer ligands featuring carbene…
Résumé Une formulation alternative de la théorie de la fonctionnelle de la densité (DFT) au-delà de l'approximation usuelle de Born—Oppenheimer (qui n'est plus valide, par exemple, lorsque l'on simule des processus photochimiques) est proposée dans ce travail. Dans cette approche, les densités…
Résumé Une description en principe exacte des excitations électroniques “double” (promotion de deux électrons des orbitales occupées dans l'état fondamental vers des orbitales de plus hautes énergies) en théorie de la fonctionnelle de la densité (DFT) est proposée. Ces dernières sont absentes des…
Abstract CPPs, or Cell-Penetrating Peptides, offer invaluable utility in disease treatment due to their ability to transport various therapeutic molecules across cellular membranes. Their unique characteristics, such as biocompatibility and low immunogenicity, make them ideal candidates for…
Abstract Metal ion-catalysed overproduction of reactive oxygen species (ROS) are believed to contribute significantly to oxidative stress and be involved in several biological processes, from immune defence to development of diseases. Among the essential metal ions, copper is one of the most…
Graphical Abstract The diradical formed by functionalizing the yttrium(III)-phthalocyaninato radical with a nitroxide radical, is characterized by an engineered g-tensor asymmetry and a weak exchange coupling. Interestingly, its behavior is reminiscent of a spin qutrit, exhibiting two EPR…
Abstract This study addresses the chemoselectivity of the catalyzed reduction of a series of variously substituted γ-lactams by Et3SiH mediated by a pentamethylcyclopentadienyl iridacyclic acetonitrilo salt derived from benzo[h]quinoline. Introduction of an unsaturation within the 5-membered ring…
Abstract Flavins and their alloxazine isomers are key chemical scaffolds for bioinspired electron transfer strategies. Their properties can be fine-tuned by functional groups, which must be introduced at an early stage of the synthesis as their aromatic ring is inert towards post-functionalization.…
Tweet The IFM team provides the first structural interpretation of the allosteric modulation at the α7 nicotinic acetylcholine receptor in collaboration with world-renowned structural biologists and electro physiologists from the University of California San Diego (USA) and the Mayo Clinic College…
Abstract In this work diamino-porphyrin derivatives, in their free base or cobalt complex forms, have been used to construct SMJs. Porphyrin oligomers were covalently bonded to a bottom electrode by diazonium cation electroreduction and a STM tip was used to complete the junction. Conductance…
Abstract Cu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone (CuII-Dp44mT) showed anticancer activity in the submicromolar concentration range in cell culture. The…
