Publications récentes

HETEROCYCLES

Abstract Natural, non-natural and ent-14β-hydroxyandrostane derivatives closely related to the cardenolide and bufadienolide skeletons were readily available through highly diastereo-/enantioselective Diels–Alder reactions calling for high pressure or Lewis acid activation. Moreover, in the…

Organic Letters

Abstract Functionalization of a methylviologen with four methyl ester substituents significantly facilitates the first two reduction steps. The easily generated radical cation shows markedly improved air stability compared to the parent methylviologen, making this derivative of interest in organic…

Chemistry : A European Journal

Abstract The allosteric control of the receptor properties of two flexible covalent cages is reported. These receptors consist of two zinc(II) porphyrins connected by four linkers of two different sizes, each incorporating two 1,2,3-triazolyl ligands. Silver(I) ions act as effectors, responsible…

Nature Research/Scientific Reports/open access

Abstract As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the emerging resistance. The methylerythritol phosphate pathway (MEP) is an ideal target for antimicrobial development as it is absent…

Chemistry : A European Journal

Abstract Copper-induced alkyne-azide cycloaddition (CuAAC), popularly known as the click-reaction, is one of the most widely used synthetic methods in the design of supramolecular scaffoldings. Whether its catalytic or stoichiometric version is concerned, the involvement of two metals in the…

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Université de Strasbourg
Centre national de la recherche scientifique | CNRS
Fondation Jean-Marie Lehn