CHAPTER 27 Noncovalent Interactions in Key Metal-centred Catalytic Intermediates: Structure–Electronic Relationship Mustapha Hamdaoui and Jean-Pierre Djukic This chapter covers the most recent advances in investigations of the most critical intermediates in transition metal-promoted processes…
Abstract Two unprecedented domino reactions are described, starting from ketospiro-enesulfonamides. By treatment with ZrCl4 and allylsilane, an intramolecular electrophilic aromatic substitution and subsequent allylation is observed. By treatment with TiCl4 and allylsilane, a double enamine-type…
Abstract Natural, non-natural and ent-14β-hydroxyandrostane derivatives closely related to the cardenolide and bufadienolide skeletons were readily available through highly diastereo-/enantioselective Diels–Alder reactions calling for high pressure or Lewis acid activation. Moreover, in the…
Abstract Functionalization of a methylviologen with four methyl ester substituents significantly facilitates the first two reduction steps. The easily generated radical cation shows markedly improved air stability compared to the parent methylviologen, making this derivative of interest in organic…
Abstract The allosteric control of the receptor properties of two flexible covalent cages is reported. These receptors consist of two zinc(II) porphyrins connected by four linkers of two different sizes, each incorporating two 1,2,3-triazolyl ligands. Silver(I) ions act as effectors, responsible…
Abstract As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the emerging resistance. The methylerythritol phosphate pathway (MEP) is an ideal target for antimicrobial development as it is absent…
Abstract Copper-induced alkyne-azide cycloaddition (CuAAC), popularly known as the click-reaction, is one of the most widely used synthetic methods in the design of supramolecular scaffoldings. Whether its catalytic or stoichiometric version is concerned, the involvement of two metals in the…
