Abstract
The failure of the therapeutic administration of superoxide dismutase (SOD) and catalase (CAT) enzymes to prevent oxidative stress has fostered the development of metal complexes that are capable of mimicking their activity. In the present work, two new pyridine azacyclophane ligands capable of coordinating Cu2+ and Fe2+ to give rise to mimetics with high activities toward disproportionation of the superoxide anion or hydrogen peroxide, depending on the metal ion, have been prepared. Although the Cu2+ complexes have some of the highest SOD activities reported to date, they are completely inactive toward H2O2 disproportionation. In contrast, the Fe2+ complexes catalyze the disproportionation of H2O2 without showing any catalytic SOD activity. Therefore, the type of antioxidant activity of these macrocycles is dictated by the nature of the metal ion, which represents a new approach to the development of potentially useful mimetics.
Reference
Tailoring Antioxidant Activities: Metal-Type Dependent, Highly Active SOD or Catalase Mimetics
Martínez-Camarena Á, Navarro-Madramany P, Castillo CE, Doménech-Carbó A, Basallote MG, Faller P, García-España E
Inorganic Chemestry, 2025 Sep 22;64(37):18938-18949 – DOI : 0.1021/acs.inorgchem.5c02973
Contact
Peter Faller (team BCB), Institut de Chimie de Strasbourg, UMR 7177.
