The inertness of copper(II) complexes can be critical for applications such as 64Cu positron emission tomography (PET). Sequence analysis of the simple peptidic amino terminal Cu(II)- and Ni(II)-binding (ATCUN) motif showed a significant improvement by introducing a tryptophan at position 4, and a stronger influence of position 2 over 1.
Optimizing the amino terminal Cu(II)- and Ni(II)-binding (ATCUN) motif for Cu(II) complexes with improved inertness
Ryan Djemili, Elise Naudin, Alice Wang, Ali Ouadi, Paulina Gonzalez, Laurent Raibaut,Peter Faller and Vincent Lebrun
Chem. Commun., 62, 3615-3618, 2026 – DOI : https://doi.org/10.1039/D5CC05119C
Peter Faller and Vincent Lebrun team BCB, Institut de Chimie de Strasbourg, UMR 7177.
