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Actualités de l'institut

janv. 14 2025

Journal of the American Chemical Society [LSAMM / POMAM / LECPCS]

Abstract: The discovery of a stable organic radical formed under mild, clean, and efficient light-mediated conditions is reported. The structure of the stable acridinium-based radical photoproduct was unambiguously established by single-crystal X-ray diffraction, mass spectrometry, and in solution by EPR, UV/vis, and NMR spectroscopies. The photochemical mechanism of its formation has been...[En savoir plus]

janv. 14 2025

Chemistry – A European Journal [LSAMM / CLIC]

Abstract: In this review, the difference between π-mers (pimers) and π-dimers (pi-dimers) will be discussed. Often interchanged or confused in the literature, these two radical interactions lead to different or even opposite physico-chemical behaviors. This review aims at clarifying the terms π-mers and π-dimers and at describing their main physico-chemical properties to address their...[En savoir plus]

déc. 9 2024

Inorganic Chemistry [BCB/POMAM]

Abstract: Imaging extracellular Cu2+ in vivo is of paramount interest due to its biological importance in both physiological and pathological states. Magnetic resonance imaging (MRI) is a powerful technique to do so. However, the development of efficient MRI contrast agents selective for Cu2+, particularly versus the more abundant Zn2+ ions, is highly challenging. We present here an innovative...[En savoir plus]

déc. 9 2024

Financement Emergence@CNRS 2025 pour Laurent RAIBAUT

L’Institut de Chimie de Strasbourg a l’honneur de vous informer que le projet «Conception d’un ligand bioinspiré à 64/67Cu pour des applications théranostiques» déposé par Laurent RAIBAUT (équipe BCB, Bométaux et Chimie Biologique) dans le cadre de l’appel à projets Emergence@CNRSChimie 2025 a été retenu pour financement. L’objectif de cet appel à projets CNRS qui est relancé pour la huitième...[En savoir plus]

déc. 2 2024

ChemBioChem [CBAT/Biogéochimie moléculaire]

Abstract: The lipid cis-trans isomerase (Cti) is a periplasmic heme-c enzyme found in several bacteria including Pseudomonas aeruginosa, a pathogen known for causing nosocomial infections. This metalloenzyme catalyzes the cis-trans isomerization of unsaturated fatty acids in order to rapidly modulate membrane fluidity in response to stresses that impede bacterial growth. As a consequence,...[En savoir plus]

nov. 29 2024

Chem. Eur. J. [POMAM / CLIC]

Abstract: The use of VIV and CuII spins to design weakly coupled and dissymmetric spin systems has been examined. Such systems were synthesized using porphyrin-based complexes, with external coordination sites allowing for the formation of dimers via a PdII linker ion. Continuous-wave (CW) Electron Paramagnetic Resonance (EPR) spectroscopy allowed the unequivocal magnetic characterization of the...[En savoir plus]

nov. 25 2024

ACS Infectious Diseases [CBAT]

Abstract: Antimicrobial resistance (AMR) poses a serious threat to global health. The rapid emergence of resistance contrasts with the slow pace of antimicrobial development, emphasizing the urgent need for innovative drug discovery approaches. This study addresses a critical bottleneck in early drug development by introducing integral solvent-induced protein precipitation (iSPP) to rapidly...[En savoir plus]