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[SOPhy] Synthèse Organique & Phytochimie

Head of the research group

Laurence MIESCHlogo
Chargée de Recherche au CNRS

Year of creation of the group - 2018 (formerly LCOS)

Location

Le Bel Institute, 4th floor South

Secretarial and accounting services provided by

Elisabeth VACCARO
email : vaccaro@unistra.fr
Phone : +33 (0)3 68 85 16 84

Permanent members

  • Laurence MIESCH
    Chargée de Recherche au CNRS
    email: lmiesch@unistra.fr
    Phone : +33 (0)3 68 85 17 51
* works for several groups
  

Non-permanent members

PhD students

  • Lucile ANDNA
  • Yongxiang ZHENG
  • Fatemeh ABDOLAHI

Research topics

1-Developing new methods in organic synthesis: Reactivity of keto-ynamides 

  • The reactivity of keto-ynamides with or without metals is being studied to access original polycyclic structures.

  • Organic reactions are being carried out in self-assembled nanoreactors in water, provviding a greener approach to synthesize valuable building blocks for natural products.

 céto-ynamides

2-Phytochemistry

Small molecules that serve as standards for elucidating biosynthetic pathways in plants are being synthesized.

  • An area of great interest is the synthesis and characterization of innovative active ingredients present in plants with therapeutic activities. This research is carried out in collaboration with Plant Advanced Technologies (PAT), a company that has developed a unique technology, "the milking plant", as an innovative asset sourcing solution: (http://www.plantadvanced.com/).

 phyto1

  • Oxidized metabolites of jasmonates that are involved plant defence are being constructed as means to identify the enzymes responsible for their formation.

 phyto2

  • Sterols are being synthesized to create new probes to understand more clearly the functions of these molecules within the plant cell.

 phyto3

  • Synthesis of intermediates of the strigolactone biosynthetic pathway (MeCLA) that promote the growth of parasitic plants. For example, Striga hermonthica, is one of the seven most serious biotic threats to food security, affecting the livelihoods of 100 million people. The goal is to understand this phenomenon to find a way to eradicate this process.

phyto4

  • Synthesis of molecules responsible for aromas in wines in collaboration with INRA.

phyto5

Description of the research group

SOPhy offers the possibility of internships (IUT, M1-M2 masters, chemistry schools ...) or to prepare a thesis at the University of Strasbourg. The group is recognized for providing excellent training in synthetic organic chemistry.

SOPhy offers research training based on preparative organic chemistry. The thesis is always considered under its double aspect of original scientific work and period of apprenticeship of a profession.

List of equiment and instruments

  • An ozonolyseur
  • A station for distillated solvents
  • A flash chromatography
  • A FT-IR spectrophotometer
  • A High Pressure system
  • An HPLC chromatography
  • A Micro-waves system

Recent publications

Lucile Andna and Laurence Miesch
Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles
Org. Lett. 2018, 20, 3430-3433

Clovis Peter, Philippe Geoffroy and Michel Miesch
Intramolecular Morita-Baylis-Hillman reaction as a strategy for the construction of tricyclic sesquiterpene cores
Org. Biomol. Chem.,2018,  16, 1381-1389

Taleb, O., Patte-Mensah, C., Meyer, L., Kemmel, V., Geoffroy, P., Miesch, M., Mensah-Nyagan, A-G.
J. Neuroendocrinol. 2018, DOI: 10.1111/jne.12568

Clovis Peter, Philippe Geoffroy and Michel Miesch
Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids
Organic Chemistry Frontiers, 2018, 5, 566

Frédéric Beltran, Indira Fabre, Ilaria Ciofini, and Laurence Miesch
Direct Spirocyclization from Keto-sulfonamides: An Approach to Azaspiro Compounds
Org. Lett., 2017, 19, 5042−5045

C. F. Heinrich, I. Fabre, L. Miesch
Silver Catalyzed 7-exo-dig Cyclization of Silylenolether-ynesulfonamides
Angew. Chem. Int. Ed. 2016, 55, 5170-5174

Photo gallery

A small overview of our research group