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[COSyS] Catalyse Organométallique, Synthèse organique et Santé

Heads of the research group

Aurélien BLANC
Chargé de Recherche au CNRS

Stefan CHASSAING
Maître de Conférences à l'Unistra

Year of creation of the group - 2024

Location

Le Bel Institute, 7th floor North

Secretarial and accounting services provided by

Geneviève STOLL
email : genstoll@unistra.fr
Phone : +33 (0)3 68 85 13 64

Permanent members

  • Patrick PALE
    Professeur à l'Unistra
    email :     ppale@unistra.fr
    Phone: +33 (0)3 68 85 15 17
  • Michel HOLLER
    Maître de Conférences à l'Unistra
    email: mholler@unistra.fr
    Phone : +33 (0)3 68 85 17 69
  • Valérie BENETEAU
    Maître de Conférences à l'Unistra
    email:     beneteau@unistra.fr
    Phone : +33 (0)3 68 85 13 44
  • Stefan CHASSAING
    Maître de Conférences à l'Unistra
    email :     chassaing@unistra.fr
    Phone : +33 (0)3 68 85 17 69
  • Aurélien BLANC
    Chargé de Recherche au CNRS
    email : ablanc@unistra.fr
    Phone: +33 (0)3 68 85 15 86
  • Jean-Marc WEIBEL
    Professeur à l'Unistra
    email: jmweibel@unistra.fr
    Phone : +33 (0)3 68 85 16 10
  • Ludovik NOËL-DUCHESNEAU*
    Assistant Ingénieur CNRS
    email :     noelduchesneau@unistra.fr
    Phone : +33 (0)3 68 85.13.09
    *Works with several team
  

Non-permanent members

PhD students, Postdocs & ATER

  • Dr Franck RAZAFINDRAINIBE
  • Dr Eliot STARCK
  • Xiaohui DI
  • Andrés PADILLA HERNÁNDEZ
  • Loïc GROSLAMBERT
  • Robin HEINRICH
  • Pierre LOCQUET
  • Eliott JUNG

Research topics

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For more information, visit our website at: http://cosys.chimie.unistra.fr/

Key publications

ORGANOMETALLIC CATALYSIS

F. Schlimpen, T. Ast, V. Bénéteau, P. Pale, S. Chassaing
From A3/KA2 to AYA/KYA Multicomponent Coupling Reactions with Terminal Ynamides as Alkyne Surrogates - a Direct, Green Route to γ-Amino-ynamides
Green Chem. 2022, 24, 6467

R. Pertschi, S. Miaskiewicz, N. Kern, J-M. Weibel, P. Pale, A. Blanc
Gold(I)-Catalyzed Divergent and Diastereoselective Synthesis of Azepines by Ammoniumation/Ring-Expansion Reactions
Chem. Catal. 2021, 1, 129

F. Schlimpen, C. Plaçais, E. Starck, V. Bénéteau, P. Pale, S. Chassaing
a-Tertiary Propargylamine Synthesis via KA2-Type Coupling Reactions under Solvent-Free CuI-Zeolite Catalysis
J. Org. Chem. 2021, 86, 16593

F. Sirindil, S. P. Nolan, S. Dagorne, P. Pale, A. Blanc, P. de Frémont
Synthesis, Characterization and Catalytic Activity of NHC Gold(I) Polyoxometalate Complexes
Chem.–Eur. J. 2018, 24, 12630

M. Teci, D. Hueber, P. Pale, L. Toupet, A. Blanc, E. Brenner, D. Matt
Metal Confinement through N-(9-Alkyl)fluorenyl Substituted N-Heterocyclic Carbenes and its Consequences in Gold-Catalysed Reactions Involving Enynes
Chem.–Eur. J. 2017, 23, 7809

S. Miaskiewicz, B. Gaillard, N. Kern, J.-M. Weibel, P. Pale, P.; A. Blanc
Gold(I)–Catalyzed N-Desulfonylative Amination versus N-to-O 1,5-Sulfonyl Migration: a Versatile Access to 1-Azabicycloalkanes
Angew. Chem., Int. Ed. 2016, 55, 9088

ORGANIC SYNTHESIS

S. Miaskiewicz, J.-M. Weibel, P. Pale, A. Blanc
Gold(I)-Catalysed Approach towards Harmalidine an Elusive Alkaloid form Peganum Harmala"
RCS Advances, 2022, 12, 26966

F. Sirindil, J.-M. Weibel, P. Pale, A. Blanc
Total Synthesis of Rhazinilam through Gold-Catalyzed Cycloisomerization-Sulfonyl Migration and Palladium-Catalyzed Suzuki-Miyaura Coupling of Pyrrolyl Sulfonates
Org. Lett. 2019, 21, 5542

E. Wimmer, S. Borghèse, A. Blanc, V. Bénéteau, P. Pale
Zeolite–Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal-Doped Zeolite–Catalyzed Steps
Chem.–Eur. J. 2017, 23, 1484

HEALTH

J. Obszynski, H. Loidon, A. Blanc, J.-M. Weibel, P. Pale
Targeted Modifications of Neomycin and Paromomycin: Towards Resistance–free Antibiotics?
Bioorg. Chem. 2022, 126, 105824

A. Farjallah, L. R. Chiarelli, M. Forbak, G. Degiacomi, M. Danel, F. Goncalves, C. Carayon, C. Seguin, M. Fumagalli, M. Zahorszka, E. Vega, S. Abid, A. Grzegorzewicz, M. Jackson, A. Peixoto, J. Kordulakova, M. R. Pasca, C. Lherbet, S. Chassaing
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA Mycobacterium tuberculosis
ACS Infect. Dis. 2021, 7, 552

N. M. Pinkerton, K. Hadri, B. Amouroux, L. Behar, C. Mingotaud, M. Destarac, I. Kulai, S. Mazières, S. Chassaing, J.-D. Marty
Quench Ionic Flash Nano-Precipitation as a Simple and Tunable Approach to Decouple Growth and Functionalization for the One-Step Synthesis of Functional LnPO4-Based Nanoparticles in Water
Chem. Commun. 2018, 54, 9438