Eur. J. Inorg. Chem. [CLAC]

Abstract

Six- and seven-membered cyclic hydroxamic acids are found as terminal binding units in different families of siderophores, including exochelins and mycobactins. The simplest models of these preorganized chelating ligands were known, but their coordination chemistry with Fe³⁺, the target metal ion of siderophores, had never been reported. Four complexes were synthesized and studied: two Fe³⁺ complexes, one with the six-membered ring hydroxamate PIPO⁻ and one with the seven-membered ring hydroxamate AZEPO⁻, and the two corresponding Ga³⁺ complexes. X-ray diffraction studies showed that the interligand repulsion energies were better minimized in the case of the AZEPO⁻ complexes whatever the metal cation considered, and that the Fe−O bond distances were shorter in [Fe(AZEPO)₃] by comparison with [Fe(PIPO)₃].

Reference

Complexes of Fe(III) and Ga(III) derived from the cyclic 6- and 7-membered hydroxamic acids found in mixed siderophores

P. Jewula, M. Grandmougin, M. Choppin, A. M. C. Tivelli, A. Amati, Y. Rousselin, L. Karmazin, J.-C. Chambron, M. Meyer

Eur. J. Inorg. Chem. 2023 (open access) - doi: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.202300038

Contact

J.-C. Chambron, équipe CLAC, Institut de Chimie de Strasbourg (UMR 7177).