ChemCatChem [LASYROC]

Abstract :

The copper(I)‐exchanged zeolite Cu^I‐USY proved to efficiently catalyze the direct azidation of arylboronic acids with sodium azide under simple and practical conditions, namely at room temperature under air with methanol as solvent and without any additive. This easy‐to‐prepare and cheap catalytic material has been demonstrated to be recyclable and the mild azidation conditions further showed good functional‐group tolerance, leading to a variety of substituted (hetero)aryl azides (18 examples). Interestingly, the azidation reaction has been successfully coupled to a CuAAC reaction, thus allowing access to triazoles from arylboronic acids via a one‐pot Cu^I‐catalyzed process.

Graphical Abstract:

 

 

 

 

 

Reference :

Arnaud Clerc, Valérie Bénéteau, Patrick Pale, Stefan Chassaing

Chan‐Lam‐type Azidation and One‐Pot CuAAC under Cu^I‐Zeolite Catalysis

ChemCatChem, first published 22 January 2020, DOI : https://doi.org/10.1002/cctc.201902058

 

Contact chercheur :

Stefan Chassaing, équipe LASYROC, Institut de Chimie (UMR 7177).