Chem. Comm. [LECPCS]

Abstract:

Two novel polyoxovanadate-iodoBodipy supramolecular assemblies, named as (2I-BDP-C₆)₂V₆ and (2I-BDP-C₆)₃V₁₀, were first synthesized by self-assembly of anionic hexavanadate and decavanadate with cationic iodoBodipy for photochemotherapy, respectively. The mechanisms for synergistic photochemotherapy of anion-cation pairs were forced on. In particular, (2I-BDP-C₆)₃V₁₀ is the first example of polyoxovanadates used for photochemotherapy which can effectively kill lung cancer cells (HepG2) by synergetic chemotherapy as well as photodynamic therapy.

 

Graphical Abstract :

 

The synthetic route (2I-BDP-C₆)₂V₆ and (2I-BDP-C₆)₃V₁₀. a, molecular structure of (2I-BDP-C₆)₂V₆, H atoms are omitted for clarity. Color code: V - orange, O - red, N - blue, C - grey, B - yellow, F - green and I - purple; b, SEM image of (2I-BDP-C₆)₃V₁₀.

 

Reference :

Polyoxovanadate-IodoBodipy Supramolecular Assemblies: New Agents for High Efficiency Cancer Photochemotherapy

Y. Gu, Q. Li, Y. Huang, Y. Zhu, Y. Wei,L. Ruhlmann

Chem. Comm. 2020,  56(19), 2869-2872 - Doi:10.1039/c9cc09944a

Contact :

L. Ruhlmann, équipe LECPCS, Institut de Chimie (UMR 7177).