Chem. Comm. [BCB]

Abstract :

The measurement of exchangeable Cu²⁺ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb³⁺ luminescent turn-off sensor for Cu²⁺ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu²⁺ detection in the presence of a biological fluorescent background.

Graphical Abstract :

Reference :

Enrico Falcone, Paulina Gonzalez, Lucie Lorusso,Olivier Sénèque, Peter Faller, and Laurent Raibaut

A terbium(III) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(II) in biological media

Chemical Communications, First Published : 26 March 2020, DOI : https://doi.org/10.1039/D0CC01007C

 

Contact chercheur :

Laurent Raibaut & Peter Faller, équipe BCB, Institut de Chimie (UMR 7177).