L'Institut de Chimie de Strasbourg a le grand plaisir de vous annoncer qu’il compte trois lauréats 2021 en son sein : Le Prof. Peter Faller (Directeur de l’équipe Biométaux et Chimie Biologique (BCB), Institut de Chimie de Strasbourg, UMR 7177), devient Membre Sénior de l’Institut Universitaire de France (IUF) à compter du 1er Octobre 2021 et pour une durée de 5 ans et se distingue également...[more]
Abstract: The measurement of labile CuII in biological samples is fundamental for understanding Cu metabolism and has been emerging as a promising diagnostic marker for Cu-related pathologies such as Wilson's and Alzheimer's diseases. The use of fluorescent chelators may be useful to circumvent separation steps employed by current methods. For this purpose, we recently designed a selective and...[more]
Tweet : The IFM team proposes a novel mechanism of operation in a synthetic molecular muscle based on all-atom Molecular Dynamics and free energy calculations. Abstract : The design of molecular architectures exhibiting functional motions is a promising area for disruptive technological development. Toward this goal, rotaxanes and catenanes, which undergo relative motions of their subunits in...[more]
Abstract : Depending on the coordination, copper ions can have a very high activity in catalyzing the production of reactive oxygen species. Thus interest arose in increasing the activity of antimicrobial peptides (AMPs) by equipping them with a Cu-binding unit. Several examples, native and engineered, have been investigated with the motif Xxx-Zzz-His, called Amino Terminal Cu(II)- and...[more]
Abstract : Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-active catalytic centre in enzymes cycling between Cu+ and Cu2+. Membrane transporters and shuttles are involved to bring and insert Cu into these enzymes and to control tightly the copper metabolism, whose failure can lead to severe diseases. The main oxidation state intracellularly is Cu+,...[more]
Abstract : Spin triangles, that is, triangular complexes of half‐integer spins, are the oldest molecular nanomagnets (MNMs). Their magnetic properties have been studied long before molecular magnetism was delineated as a research field. This Review presents the history of their study, with references to the parallel development of new experimental investigations and new theoretical ideas used...[more]
L’institut de chimie de Strasbourg (UMR7177) est heureux de vous informer que le projet ITN Européen ALLOD (“Allosteric Drug Design") déposé par l’équipe IFM (Laboratoire d'Ingénierie des Fonctions Moléculaires dirigé par Marco Cecchini) comme cosignataire a été sélectionné par la Commission Européenne pour être financé. Le réseau est composé de 13 partenaires européens dont 3 entreprises...[more]