Abstract : Photoallergic contact dermatitis is a skin disease caused by combined exposure to photoreactive chemicals and sunlight. Exposure to allergens and the risk of skin sensitization is an essential regulatory issue within the industry. Yet, only few non-validated assays for photoallergy assessment exist as the pathogenesis is not fully deciphered. Improving such assays and/or developing...[more]
Abstract: Organofluorines have a broad range of industrial applications, such as pharmaceutics, liquid crystal displays (LCD), solar cells, textiles, and construction coatings, and are used in peptidomimetics, surfactants, refrigerants, anesthetics, and agrochemicals. Among them are versatile monofluoroalkenes that play a crucial role in medicinal and synthetic chemistry. The synthetic...[more]
Abstract : A method for the construction of trifluorinated-5-methylenepyrrolidinone is reported. This strategy combines an acid-catalyzed two-carbon homologation process between ynamides and aldehydes, providing CF3-substituted dienes followed by a metal-free domino hydroamination/isomerization/transamidation sequence, delivering trifluorinated-5-methylenepyrrolidinone...[more]
Graphical Abstract An asymmetric diradical was synthesized by grafting a nitroxide radical onto the [Y(Pc)2]⋅ radical system. The molecule was shown to exhibit a weak exchange interaction between its two radical units. The g-asymmetry combined with the magnetic interaction led to the electron paramagnetic resonance transition of different tipping angles, which could be selectively enhanced by...[more]
Abstract: The controlled growth of self-assembled networks on surfaces based on viologen salts is a major scientific challenge due to their unique electronic properties. The combination of solid-state NMR spectroscopy and atomic force microscopy at ambient conditions can unravel the fine organization of the supramolecular network on a graphitic surface by positioning the counter-ions relative to...[more]
L’Institut de Chimie de Strasbourg a le grand plaisir de vous annoncer que : - Maxime HOURTOULE, déjà lauréat du Prix de thèse SCF-Alsace 2023, s’est vu décerner le Prix de thèse de la Société des Amis des Universités de l'Académie de Strasbourg (Prix de thèse de l’École Doctorale des Sciences Chimiques 2024, ED222, Université de Strasbourg). Maxime Hourtoule a effectué sa thèse sous la...[more]
Abstract: This work merges two different types of many-electron ensembles, namely, the Theophilou-Gross-Oliveira-Kohn ensembles of ground and neutrally excited states, and the more recent 𝑁-centered ensembles of neutral and charged ground states. On that basis, an in-principle exact and general, so-called extended 𝑁-centered, ensemble density functional theory of charged and neutral electronic...[more]