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News
Soutenance de thèse de doctorat de Johnny Hu
Soutenance de thèse de doctorat de Johnny Hu Lundi 28 novembre 2022 à 9h00, dans l'amphithéâtre Alain Beretz (nouveau patio) sur le campus Esplanade. Ce travail a été effectué au sein de l’équipe LSAMM (Institut de Chimie, UMR 7177).[more]
Comprehensive Organometallic Chemistry IV - Volume 8 [LCC]
Comprehensive Organometallic Chemistry IV (Fourth Edition) N-Heterocyclic Carbene Complexes of Nickel Volume 8, 2022, Pages 427-574 - DOI: https://doi.org/10.1016/B978-0-12-820206-7.00118-9 Ligielli Irene, Danopoulos Andreas A., Braunstein Pierre and Simler Thomas Abstract: The impact of N-heterocyclic carbene (NHC) ligands across the Periodic Table in the last twenty years can be compared...[more]
Comprehensive Organometallic Chemistry IV - Volume 7 [LCC]
Comprehensive Organometallic Chemistry IV (Fourth Edition) N-Heterocyclic Carbene Complexes of Cobalt Volume 7, 2022, Pages 632-758- DOI: https://doi.org/10.1016/B978-0-12-820206-7.00109-8 Simler Thomas, Danopoulos Andreas A. and Braunstein Pierre Abstract: N-heterocyclic carbenes (NHCs) have become ubiquitous ligands across the Periodic Table and enjoy a growing impact on various aspects...[more]
Organic & Biomolecular Chemistry [SOPhy]
Abstract: The two-faced reactivity of N-allenamides allows regio-and stereo-controlled functionalization on the a-, b- and γ-positions of the nitrogen atom. The contingency to obtain either proximal or distal adducts, makes those substrates essential for the construction of complex heterocyclic scaffolds. This review covers recent advances made in the development of new methods involving...[more]
Biomolecules [BCB]
Abstract: The progressive, neurodegenerative Alzheimer’s disease (AD) is the most widespread dementia. Due to the ageing of the population and the current lack of molecules able to prevent or stop the disease, AD will be even more impactful for society in the future. AD is a multifactorial disease, and, among other factors, metal ions have been regarded as potential therapeutic targets. This is...[more]
Chem. Sci. [BCB]
Abstract: Copper (Cu) in its ionic forms is an essential element for mammals and its homeostasis is tightly controlled. Accordingly, Cu-dyshomeostasis can be lethal as is the case in the well-established genetic Wilson's and Menkes diseases. In Alzheimer's disease (AD), Cu-accumulation occurs in amyloid plaques, where it is bound to the amyloid-beta peptide (Aβ). In vitro, Cu–Aβ is competent to...[more]
Science Advances [IFM]
Abstract: Glycine receptors (GlyRs) are ligand-gated ion channels that mediate signal transduction at chemical synapses. Since the early patch-clamp electrophysiology studies, the details of the ion permeation mechanism have remained elusive. Here, we combine molecular dynamics simulations of GlyR-α1 with mutagenesis and single-channel electrophysiology and show that lateral fenestrations...[more]