Abstract The redox activity of Cu ions bound to the amyloid-β (Aβ) peptide is implicated as a source of oxidative stress in the context of Alzheimer's disease. In order to explain the efficient redox cycling between Cu(II)-Aβ (distorted square pyramidal) and Cu(I)-Aβ (digonal) resting states, the existence of a low-populated "in-between" state, prone to bind Cu in both oxidation states, has been...[more]
Abstract We report herein a domino reaction to construct 2-amido-5-fluoropyrroles from CF3-substituted N-allenamides. The in situ generated gem-difluorinated ene-ynamides derived from CF3-substituted N-allenamides, when subjected to silver catalysis with a primary amine, undergo simultaneous hydroamination of the ynamide moiety followed by a 5-endo-trig addition/β-fluoride elimination sequence,...[more]
L’Institut de Chimie de Strasbourg a le grand plaisir de vous annoncer que Pablo Roseiro (doctorant dans l’équipe LCQ, Institut de Chimie de Strasbourg, UMR 7177) a été sélectionné parmi les 12 finalistes au concours Ma thèse en 180 secondes. Félicitations et bonne chance à lui pour la finale ! Si vous souhaitez soutenir Pablo Roseiro : - Le Jeudi 9 mars, la finale Alsace 2023 du concours...[more]
Mercredi 1er mars à 9 h 30 dans l'amphithéâtre du Collège Doctoral Européen (Université de Strasbourg, Campus de l’Esplanade). Titre : "Systèmes antioxydants versus prooxydants lors d’évènements dermatologiques : Nouvelle approche par RPE pour étudier les espèces radicalaires induites par des xénobiotiques dans la peau" Cette thèse a été effectuée sous la direction du Dr. Elena GIMÉNEZ-ARNAU...[more]
Abstract 3,3',3''-(Benzene-1,3,5-triyl)tris(1-phenyl-1H-benzo[e][1], [2], [4]triazin-4-yl) (1) is a C3-symmetrical triradical comprised of three Blatter radical units connected at the 1, 3, 5 positions of a central trimethylenebenzene core. This triradical has an excellent air, moisture, and thermal stability. Single-crystal XRD indicates that triradical 1 adopts a propeller-like geometry with...[more]
Abstract Potential inversion refers to the situation where a protein cofactor or a synthetic molecule can be oxidized or reduced twice in a cooperative manner; that is, the second electron transfer is easier than the first. This property is very important regarding the catalytic mechanism of enzymes that bifurcate electrons and the properties of bidirectional redox molecular catalysts that...[more]
Abstract Two novel compounds isolated from an amber sample from the Santonian of Piolenc (Vaucluse, SE France) were identified using nuclear magnetic resonance and high-resolution mass spectrometry as sulfurized analogues of diterpenic acids from the isopimaric series originating from ancient conifers possibly related to the Cupressaceae family. These two compounds are members of a diterpenoid...[more]