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- Biogéochimie moléculaire
- [BCB] Biométaux et Chimie Biologique
- [CLIC] Coordination, Ligands, Interactions et Catalyse
- [CBMB] Chimie et Biochimie de Molécules Bioactives
- [LCQS] Chimie Quantique de Strasbourg
- [LECPCS] Electrochimie et Chimie Physique du Corps Solide
- [COSyS] Catalyse Organométallique, Synthèse organique et Santé
- [SOPhy] Synthèse Organique & Phytochimie
- [LSAMM] Synthèse des Assemblages Moléculaires Multifonctionnels
- [LCSOM] Chimie et Systémique Organo-Métalliques
- [CBAT] Chimie Biologique et Applications Thérapeutiques
- [ECMC] Confinement Moléculaire et Catalyse
- [POMAM] Propriétés Optiques et Magnétiques des Architectures Moléculaires
- Biophysique des membranes et RMN
- [IFM] Laboratoire d’Ingénierie des Fonctions Moléculaires
- [SRCO] Synthèse, Réactivité et Catalyse Organométalliques
- [OMECA] Objets, MEtaux et CAtalyse
- [SOCAT] Synthèse Organométallique et CATalyse
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News
Chem. Eur. J. [POMAM / CLIC]
Abstract: The use of VIV and CuII spins to design weakly coupled and dissymmetric spin systems has been examined. Such systems were synthesized using porphyrin-based complexes, with external coordination sites allowing for the formation of dimers via a PdII linker ion. Continuous-wave (CW) Electron Paramagnetic Resonance (EPR) spectroscopy allowed the unequivocal magnetic characterization of the...[more]
ACS Infectious Diseases [CBAT]
Abstract: Antimicrobial resistance (AMR) poses a serious threat to global health. The rapid emergence of resistance contrasts with the slow pace of antimicrobial development, emphasizing the urgent need for innovative drug discovery approaches. This study addresses a critical bottleneck in early drug development by introducing integral solvent-induced protein precipitation (iSPP) to rapidly...[more]
Org. Chem. Front. [SOPhy]
Abstract: A totally controlled regiodivergent azidation of activated N-allenamides is presented. Using TMSN3/TBAF, β-azidation of N-allenamides occurs exclusively, yielding vinyl azides. Conversely, employing a TFA/TMSN3 mixture results solely in the formation of γ-azides. A subsequent formal Winstein rearrangement of the latter with DBU produces α-amido vinyl azides. Additionally,...[more]
Nature Communications [IFM]
Tweet: The IFM team in collaboration with researchers at ENS Lyon and Institut Pasteur used advanced molecular simulations to investigate how cannabinoids bind to glycine receptors, an important pharmacological target for chronic pain. They discovered that tetrahydrocannabinol (THC) and anandamide (AEA) bind to more than one region of the receptor's transmembrane domain and characterized their...[more]
Prix de stage RJ- SCF-ALSACE: deux Lauréats pour l'UMR 7177
Félicitations à Fatih YILDIRIM et Titien SIMON, lauréats (première édition !) du prix de stage RJ- SCF-ALSACE (Réseau des Jeunes chimistes- Société Chimique de France - ALSACE). - Fatih YILDIRIM pour son stage de M1 (CHIMIE-PHYSIQUE INFORMATIQUE ANALYTIQUE & MATÉRIAUX, CPIAM) effectué au sein de l’Institut de Chimie de Strasbourg (UMR 7177), dans le Laboratoire de Chimie Quantique de...[more]
Angew Chem Int Ed [BCB/POMAM]
Abstract: Several copper-ligands, including 1,10-phenanthroline (Phen), have been investigated for anticancer purposes based on their capacity to bind excess copper (Cu) in cancer tissues and form redox active complexes able to catalyse the formation of reactive oxygen species (ROS), ultimately leading to oxidative stress and cell death. Glutathione (GSH) is a critical compound as it is highly...[more]
Nature Communications [ECMC]
Abstract: When aiming at the direct use of CO2 for the preparation of advanced/value-added materials, the synthesis of CO2/olefin copolymers is very appealing but challenging. The δ-lactone 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one (EVP), synthesized by telomerization of CO2 with 1,3-butadiene, is a promising monomer. However, its chemoselective ring-opening polymerization (ROP) is hampered...[more]