- Présentation
- Équipes de Recherche
- Biogéochimie moléculaire
- [BCB] Biométaux et Chimie Biologique
- [CLIC] Coordination, Ligands, Interactions et Catalyse
- [CBMB] Chimie et Biochimie de Molécules Bioactives
- [LCQS] Chimie Quantique de Strasbourg
- [LECPCS] Electrochimie et Chimie Physique du Corps Solide
- [COSyS] Catalyse Organométallique, Synthèse organique et Santé
- [SOPhy] Synthèse Organique & Phytochimie
- [LSAMM] Synthèse des Assemblages Moléculaires Multifonctionnels
- [LCSOM] Chimie et Systémique Organo-Métalliques
- [CBAT] Chimie Biologique et Applications Thérapeutiques
- [ECMC] Confinement Moléculaire et Catalyse
- [POMAM] Propriétés Optiques et Magnétiques des Architectures Moléculaires
- Biophysique des membranes et RMN
- [IFM] Laboratoire d’Ingénierie des Fonctions Moléculaires
- [SRCO] Synthèse, Réactivité et Catalyse Organométalliques
- [OMECA] Objets, MEtaux et CAtalyse
- [SOCAT] Synthèse Organométallique et CATalyse
- Services scientifiques
- Actualités de l'institut
- Agenda - Conférences
- Annuaires CNRS et Université
Abstract: Imaging extracellular Cu2+ in vivo is of paramount interest due to...
L’Institut de Chimie de Strasbourg a l’honneur de vous informer que le projet...
Publications récentes
Metallomics [BCB/POMAM/Biophysique des membranes et RMN]
Abstract: Metal ion-catalysed overproduction of reactive oxygen species (ROS) are believed to contribute significantly to oxidative stress and be involved in several biological processes, from immune defence to development of diseases. Among the essential metal ions, copper is one of the most efficient catalysts in ROS production in the presence of O2 and a physiological reducing agent such as...[En savoir plus]
Chemistry – A European Journal [POMAM]
Graphical Abstract The diradical formed by functionalizing the yttrium(III)-phthalocyaninato radical with a nitroxide radical, is characterized by an engineered g-tensor asymmetry and a weak exchange coupling. Interestingly, its behavior is reminiscent of a spin qutrit, exhibiting two EPR transitions characterized by different Rabi frequencies and whose amplitudes can be selectively enhanced by...[En savoir plus]
Organometallics [LCSOM/ Biophysique des membranes et RMN]
Abstract: This study addresses the chemoselectivity of the catalyzed reduction of a series of variously substituted γ-lactams by Et3SiH mediated by a pentamethylcyclopentadienyl iridacyclic acetonitrilo salt derived from benzo[h]quinoline. Introduction of an unsaturation within the 5-membered ring of the γ-lactam annihilates the precedence of the amide function over the capture of the silylium...[En savoir plus]
Angewandte Chemie [OMECA/LCQ/POMAM]
Abstract: Flavins and their alloxazine isomers are key chemical scaffolds for bioinspired electron transfer strategies. Their properties can be fine-tuned by functional groups, which must be introduced at an early stage of the synthesis as their aromatic ring is inert towards post-functionalization. We show that the introduction of a remote metal-binding redox site on alloxazine and flavin...[En savoir plus]
Cell [IFM]
Tweet: The IFM team provides the first structural interpretation of the allosteric modulation at the α7 nicotinic acetylcholine receptor in collaboration with world-renowned structural biologists and electro physiologists from the University of California San Diego (USA) and the Mayo Clinic College of Medicine and Science in Rochester (USA). These results appeared in Cell (IF 66,85) have...[En savoir plus]
J. Mater Chem. C. [CLIC]
Abstract In this work diamino-porphyrin derivatives, in their free base or cobalt complex forms, have been used to construct SMJs. Porphyrin oligomers were covalently bonded to a bottom electrode by diazonium cation electroreduction and a STM tip was used to complete the junction. Conductance versus time (G(t)) measurements reveal stable SMJs with lifetimes as long as 70 s, attributable to the...[En savoir plus]
Chemistry – A European Journal [BCB / POMAM]
Abstract Cu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone (CuII-Dp44mT) showed anticancer activity in the submicromolar concentration range in cell culture. The interaction of CuII-Dp44mT with thiols leading to their depletion or inhibition was proposed to be...[En savoir plus]