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[LASYROC] Synthèse et réactivité organiques et Catalyse

Head of the research group

Patrick PALE
Professeur à l'Unistra

Year of creation of the group- 1995


Le Bel Institute, 7th floor North

Secretarial and accounting services provided by

Françoise ROTHHUT
Phone: +33 (0)3 68 85 65 33

Permanent members

  • Patrick PALE
    Professeur à l'Unistra
    email :
    Phone: +33 (0)3 68 85 15 17
  • Victor MAMANE
    Chargé de Recherche au CNRS
    email: vmamane@unistra.fr
    Phone : +33 (0)3 68 85 16 12
  • Valérie BENETEAU
    Maître de Conférences à l'Unistra
    Phone : +33 (0)3 68 85 13 44
  • Stefan CHASSAING
    Maître de Conférences à l'Unistra
    email :
    Phone : +33 (0)3 68 85 16 12
  • Aurélien BLANC
    Chargé de Recherche au CNRS
    email : ablanc@unistra.fr
    Phone: +33 (0)3 68 85 15 86
  • Jean-Marc WEIBEL
    Professeur à l'Unistra
    email: jmweibel@unistra.fr
    Phone : +33 (0)3 68 85 16 10
* work for several groups  

Non-permanent members

PhD students

  • Fatih SIRINDIL
  • Olesia ZAITCEVA
  • Romain PERTSCHI
  • Robin WEISS
  • Hugo LOIDON
  • Giovany MARIE-ROSE

Research topics

1- Total synthesis of bioactive products: 
Biologically active compouds are selected as targets either to set up new strategies and new methods, or to highlight the methodologies we develop in other contexts (see below).


2- New methodologies :
We are developing new methods within the context of Green Chemistry, based on homogeneous and/or heterogeneous catalysis (see below) but also on the use of enzymes and/or carbohydrates.

3. Homogeneous catalysis :
We explore the behavior of selected transition metal catalysis and organometallics, mainly Cu, Ag, Au, in organic synthesis. The mehods we developed are then applied to total synthesis of natural products.

4- Heterogeneous catalysis :
Heterogeneous catalysis is at the heart of many industrial processes, but not much in organic synthesis. We are thus trying to combine both by conceiving and synthesizing new micro-and mesoporous materials, tuned for catalysis, either towards organic synthesis (see § Green Chem.), or towards industrial problems, such as carbonylation, chloration,...

  • Multifonctional catalysis: Polyoxometalates (POM) provide an interesting opportunity to develop new and multifunctional catalysts. We are currently developing Ag, Au-POMs.
  • Chiral heterogeneous catalysis : Metal organic frameworks (MOF) made of specially designed chiral ligands offer to develop new chiral and heterogeneous catalysts.

catalyse hétérogène chirale

5- Green Chemistry :
Towards greener chemistry, we are looking for recyclable, if possible multifunctional, catalysts and applying them in multicomponent and cascade reactions.

  • "Zeo-click synthesis" : Zeolites doped with metals provided a peculiar environment for organic transformations, behaving as nanoreactors and forcing some reactions to proceed, together with new or improved or even reversed (stereo)selectivities. Zeo-click synthesis
  • Zeo-based organic synthesis : We are trying to apply zeo-click chemistry to total synthesis, such as in our Acortatarin synthesis.

 synthèse organique à base de zéolithes

6- Chemical tools in biology:
From known RNA 3D structures (X ray, etc), we designed and prepared compounds binding to specific sequences. Biological evaluations showed that this concept is indeed offering new routes towards new antiviral and new antibiotic drugs.

Key publications

D. Hueber, M. Hoffmann, B. Louis, P. Pale, A. Blanc
Inorganic-organic heteropolyacid-gold(I) hybrid: Structure and applications in catalysis
Chem. Eur
. J. 2014, 20, 3903

P. Losch, A-S. Felten, P. Pale
Easy, green and safe carbonylation reactions through zeolite-catalyzed CO production from formic acid
Adv. Cat. Synth.
2015, 357, 2931

S. Miaskiewicz, B. Gaillard, N. Kern, J-M. Weibel, A. Blanc, P. Pale
Gold(I)-catalyzed N-desulfonylative amination versus N-to-O 1,5-sulfonyl migration: a versatile access to 1-azabicycloalkanes
Angew. Chem. I. E.
2016, 55, 9088

E. Wimmer, S. Borghèse, A. Blanc, V. Bénéteau, P. Pale
Zeolite-based organic synthesis (ZeoBOS) of Acortatarin A: 1st total synthesis based on native and metal doped-zeolite-catalyzed steps
Eur. J. 2017, 23, 1484

E. Aubert, M. Abboud, A. Doudouh, P. Durand,  P. Peluso, , A. Ligresti, B. Vigolo P. Pale, V. Mamane
Silver(I) coordination polymers with 3,3’,5,5’-tetrasubstituted 4,4’-bipyridine ligands: towards new porous chiral materials
RCS Advances
2017, 7, 7358

Photo gallery

A small overview of our research group...