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Recent publications

Dec 21 2018

Nature Research/Scientific Reports/open access [CBAT]

Abstract : As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the emerging resistance. The methylerythritol phosphate pathway (MEP) is an ideal target for antimicrobial development as it is absent in humans but present in most bacteria and in the parasite Plasmodium falciparum. Here, we report...[more]

Dec 20 2018

Organic Chemistry Frontiers [SOPhy]

Abstract : Spirocyclization of keto-ynamides with quaternary ammonium salts was performed to access aza-spiro compounds. Exclusive E-configured 5-exo-dig compounds were isolated from keto-ynamides substituted by an aryl- or a vinyl group, whereas 6-endo-dig compounds were favored from terminal ynamides. Reference : Frédéric Beltran, Lucile Andna and Laurence Miesch Spirocyclization of...[more]

Dec 6 2018

Chemistry : A European Journal [ECMC, SOCAT, LCSOM]

Abstract : A new way of introducing a N-heterocyclic carbene cap onto cyclodextrins has been devised. The benzimidazolium intermediates were found to behave as receptors towards cavity matching anions. The corresponding C1- and C2-symmetrical regioisomeric carbene gold(I) complexes have been tested in a benchmark asymmetric cycloisomerization of 1,6-enynes. Up to 50% ee was achieved for the...[more]

Nov 15 2018

Chem. Commun. [BCB]

Summary : Copper and zinc trafficking in and around cells, mainly between proteins, is a very fundamental and essential process in most living organisms and impairment of such trafficking can be lethal, like well documented in the genetic Cu-overload Wilson  diseases. Moreover, the metabolism of these essential metal ions Cu and Zn are connected (e.g. Wilsons disease can be treated by Zn...[more]

Nov 8 2018

Bioconjugate Chem. [LSAMM]

Abstract: A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear p-conjugated Zn(II)-porphyrin dimer linked at each extremity to a GdDOTA-type complex. This agent has shown very promising potential for PDT applications with good singlet oxygen...[more]

Nov 8 2018

Inorg. Chem. [POMAM]

Synopsis
: The electron paramagnetic resonance spectrum of a highly symmetric chromium(III) spin triangle has revealed highly anisotropic and broadened features. These have been analyzed by full Hamiltonian methods, which consider simultaneous distributions of its isotropic and antisymmetric exchange (Dzyaloshinskii−Moriya) interaction parameters. The examination of several broadening models has...[more]

Oct 19 2018

Chemistry : A European Journal [CLAC]

Abstract : Porphyrins are conjugated, stable chromophores with a central core that binds a variety of metal ions and an easily functionalized peripheral framework. By combining the catalytic, electronic or cytotoxic properties of selected transition metal complexes with the binding and electronic properties of porphyrins, enhanced characteristics of the ensemble are generated. This review...[more]