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Recent publications

Jun 8 2022

Food and Chemical Toxicology [Dermatochimie/LCQ/POMAM]

Abstract: Citronellol, one of the most used fragrance compounds worldwide, is one ingredient of Fragrance Mix II used to assess skin allergy to fragrances in dermatitis patients. Pure citronellol is non-allergenic. Main issue is it autoxidizes when exposed to air becoming then allergenic. The increased skin sensitizing potency of air-exposed citronellol has been attributed to the hydroperoxides...[more]

Jun 1 2022

Chem. Eur. J. [CBAT] + Cover

Abstract: IspG (also called GcpE) is an oxygen-sensitive [4Fe-4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated target for drug development. It converts 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate (MEcPP) into (E)-4-hydroxy-3-methyl-but-2-enyl-1-diphosphate (HMBPP). The reaction, assimilated to a reductive dehydration, involves redox...[more]

Jun 1 2022

Molecules [CBAT]

Abstract: The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. The absence of this pathway in mammalians makes it an interesting target for the discovery of novel anti-infectives. As last enzyme of this pathway,...[more]

May 20 2022

Organic Letters [SOPHY]

Abstract: The first synthesis of gem-difluorinated ene–ynamides is presented via deprotonation of trifluoromethylated N-allenamides and δ extrusion of fluorine. These highly reactive building blocks, owing to their dual functional groups, offer a unique entry to difluorinated dienes and to stereodefined, monofluoro-substituted dienes. Stereoselective addition to the ynamide moiety led to...[more]

May 16 2022

J. Org. Chem. [SOPHY]

Abstract: A synthesis of new-to-nature aza-iridoids via ynamides is presented. ZrCl4 proved to be the best acid to perform this transformation. Various ynamides were accommodated, and seco-iridoids could be obtained as well. Aza-iridoids were infiltrated into leaves of Scrophularia Nodosa, an iridoid-producing plant species. High-resolution mass spectrometry coupled to computational metabolomic...[more]

May 9 2022

Actualités de l’INC [Biophysique des membranes et RMN]

L’Institut de Chimie de Strasbourg a le plaisir de vous annoncer que l’article « Inorganic phosphate in growing calcium carbonate abalone shell suggests a shared mineral ancestral precursor » récemment publié dans Nature Communication, auquel Philippe Bertani (équipe Biophysique des membranes et RMN, Institut de Chimie de Strasbourg, UMR 7177) a collaboré, vient de faire l’objet d’une...[more]

May 5 2022

ChemPhysChem [LCQ] + Cover

Abstract: Combination of spin crossover metal ion and open-shell environment results in the mixing of high- and low- spin metal states, named as spinmerism.   The spin states of a Co(II) oxoverdazyl compound are investigated by means of wavefunction-based calculations. Within a ca. 233 K energy window, the ground state and excited states display a structure-sensitive admixture of low-spin...[more]