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Organic Letters

May 30 2018
Organic letters

Enamides equipped with N-acyliminium ion precursors were obtained through reduction of ynamides tethered to N-imides. Intramolecular TMSOTf-mediated trapping of N-acyliminium ions provided a variety of polyfunctionalized medium-sized diaza-heterocycles of putative pharmacological interest.

 graphical abstract

Référence :

Lucile Andna and Laurence Miesch
Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles
Organic Letters, Mai 2018  doi: 10.1021/acs.orglett.8b01407

Contact chercheur:

L.Miesch, Institut de Chimie de Strasbourg
Courriel : lmiesch@unistra.fr