Abstract :
Spirocyclization of keto-ynamides with quaternary ammonium salts was performed to access aza-spiro compounds. Exclusive E-configured 5-exo-dig compounds were isolated from keto-ynamides substituted by an aryl- or a vinyl group, whereas 6-endo-dig compounds were favored from terminal ynamides.
Reference :
Frédéric Beltran, Lucile Andna and Laurence Miesch
Spirocyclization of Keto-Ynamides Promoted by Quaternary Ammonium Salts
Org. Chem. Front. 2018, DOI: 10.1039/C8QO00937F
Contact chercheur :
Laurence Miesch, SOPhy, Institut de Chimie (UMR 7177).