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Organic Chemistry Frontiers [SOPhy]

Dec 20 2018

Abstract :

Spirocyclization of keto-ynamides with quaternary ammonium salts was performed to access aza-spiro compounds. Exclusive E-configured 5-exo-dig compounds were isolated from keto-ynamides substituted by an aryl- or a vinyl group, whereas 6-endo-dig compounds were favored from terminal ynamides.

Reference :

Frédéric Beltran, Lucile Andna and Laurence Miesch

Spirocyclization of Keto-Ynamides Promoted by Quaternary Ammonium Salts

Org. Chem. Front. 2018, DOI: 10.1039/C8QO00937F

Contact chercheur :

Laurence Miesch, SOPhy, Institut de Chimie (UMR 7177).