EurJOC [ECMC]

Abstract :

Gold(I) complexes containing monodentate P^III ligands built upon methylated α-cyclodextrins have been synthesized and assessed in the cycloisomerization of 1,6-enynes, two of the reactions studied involving prochiral substrates. Their performance was compared with that of previously reported mononuclear and dinuclear α- and β‐cyclodextrin-based Au^I complexes. Enantiodiscrimination was found to be strongly dependent on the ability of the ligand to position metal-coordinated substrates inside the cyclodextrin core.

Graphical Abstract :

Reference :

Zeyneb Kaya, Lucile Andna, Dominique Matt, Embarek Bentouhami, Jean‐Pierre Djukic, Dominique Armspach

A Comparative Study of Confining Ligands Derived from Methylated Cyclodextrins in Gold-Catalyzed Cycloisomerization of 1,6-Enynes

EurJOC - DOI: 10.1002/ejoc.201900631

Contact chercheur :

Dominique Armspach, équipe ECMC, Institut de Chimie (UMR 7177).