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[LCSOM] Chimie et Systémique Organo-Métalliques

Head of the research group

Jean-Pierre DJUKIC
Directeur de recherche CNRS

Year of creation of the group - 2014

Group's website

http://lcsom.u-strasbg.fr

Secretarial and accounting services provided by

Geneviève STOLL
email: genstoll@unistra.fr
Phone: +33 (0)3 68 85 13 64

Permanent members

  • DJUKIC Jean Pierre
    Directeur de recherche au CNRS
    email : djukic@unistra.fr
    Phone: +33 (0)3 68 85 15 23
  • PFEFFER Michel
    Directeur de recherche émérite au CNRS
    email : pfeffer@unistra.fr
    Phone: +33 (0)3 68 85 15 24

Non-permanent members

PhD students:

Postdocs:

Description of the research group

The Laboratory of Chemistry and Systemic Organometallic was founded January 1, 2014 as a new research team at the Institute of Chemistry of Strasbourg (UMR 7177, CNRS, University of Strasbourg).


LCSOM is developing experimental research in the field of Organometallic Chemistry of transition metal complexes of the " d block " of the Periodic Table of Elements.
Historically, its researchers, mainly from the Laboratory of Metalloinduced Syntheses (LSMI, formerly headed by Michel Pfeffer), are interested in the properties of metallacycles derived from aromatic ligands.  The field of research has expanded since about ten years to cover disciplinary fields at the interfaces of conventional experimental organometallic chemistry with the integration of DFT modeling and calorimetry methods. 


LCSOM covers the disciplines of green chemistry, bio-organometallic chemistry and supramolecular chemistry with the use of modern and efficient methods of investigation.


LCSOM's goal is to continue fundamental research in organometallic chemistry while maintaining strong synthesis activity; know-how in the chemistry of metallacycles, in the development of new concepts of coordination chemistry (hemichelation and multicenter bonds) and in the systemic study of complex chemical systems, that is to say, the combined effects of complex environment (solvation, non-covalent interactions, light irradiation, multicomponent mixtures) on the course of chemical transformations involving organometallic complexes of transition metals as core species. A central point of interest is the study of tandem catalytic systems or multicomponent catalytic systems in a single reactor where the comprehension of the kinetic regulation rules of successive reactions and non-productive processes or catalyst poisoning is central.

Research topics

The current main lines of the LCSOM, successor of the LSMI on January 1st, 2014, are the illustration of this diversification:

  • research on complex catalytic systems (multicomponent tandem catalysis reaction, catalysis for the production of small energetic molecules, multicomponent catalysis of C-H, Si-H, B-H, C-F activation)
  • fundamental studies on the impact of non-covalent interactions and London's strength in transition metal complex chemistry
  • development of the concept of hemichelation, formulation of complex situations of interactions at three centers
  • synthesis of cytotoxic complexes for specific treatment of cancers
  • development of methodologies for the synthesis of planar chirality complexes and their application to the above-mentioned topics

These axes call upon numerous interdisciplinary collaborations and new own resources exploited within the LCSOM: DFT calculation (more than 40 physical cores), calorimetric titration (ITC in "clean" glove box).

LCSOM also develops ad hoc measurement equipment for catalysis monitoring based on the assembly of custom-made glassware, pressure probes, hydrogen and analog / logic converter boards for acquisition in real time of characteristic observables

This once marginal activity is taking off again with the setting up of a collaboration with researchers at UMR iCube in order to develop new technologies for monitoring liquid phase catalysis.

LCSOM also participates in numerous collaborations in the field of energy storage, homogeneous catalysis and fundamental studies on the role of the London force for cohesion in chemistry, with co-supervision theses. On the latter subject, a research consortium with the Laboratory of Theoretical Chemistry of the University of Bonn (Prof. S. Grimme) has been recognized by the french ANR and the german DFG.

 

drawing

List of equipment and instruments

LCSOM benefits from four modern laboratories equipped with ventilated hoods all supplied with fluids (electricity, argon gas, raw water, nitrogen and helium supply option).
For the purposes of synthesis and other specific manipulations, a VacAtmospheres glove box under argon atmosphere is placed in a shared air-conditioned room.

 A series of analytical measuring instruments are dispatched in different rooms:

  • HP gas chromatograph
  • Varian analytical HPLC chain (chiral columns, reverse and normal phases)
  • UV-Visible absorption spectrometer
  • Bruker compact FT-IR spectrometer (ATR and transmission)
  • isothermal titration calorimeter nano-ITC 1mL TA (in glove box "clean" MBraun air-conditioned and equipped with a freezer)
  • A server bay under debian LINUX_ (40 Intel & AMD physical cores) is intended for DFT computing for laboratory use with routine recourse to the following packages: SCM-ADF, ORCA.

The reagents are listed in a computer database and stored in a special ventilated room.
Additional ventilated cupboards are distributed in the lab for the storage of non-volatile products and gas cylinders.

Career opportunities

CNRS, Universities, chemical industry (fine and pharmaceutical).  Collaborations with several academic and industrial centers in Holland, Germany, Great Britain, Spain, Serbia, Brazil, USA, Mexico, Australia, Japan, etc ...

Key publications

Dang Ho Binh, Milan Milovanovic, Julia Puertes-Mico, Mustapha Hamdaoui, Snezana D. Zaric, and Jean-Pierre Djukic
'Is the R3si Moiety in Metal-Silyl Complexes a Z Ligand An Answer from the Interaction Energy'
Chem. - Eur. J., 23 (2017), 17058-69

Francoise Colobert, Quentin Dherbassy, Jean-Pierre Djukic, and Joanna Wencel-Delord
'Two Chiral Events in a Single C-H Activation Step: A Route Towards Terphenyl Ligands with Two Atropisomeric Axes'
Angew Chem Int Ed Engl (2018)

Mustapha Hamdaoui, Camille Desrousseaux, Houda Habbita, and Jean-Pierre Djukic
'Iridacycles as Catalysts for the Autotandem Conversion of Nitriles into Amines by Hydrosilylation: Experimental Investigation and Scope'
Organometallics, 36 (2017), 4864-82

Christophe Werle, Corinne Bailly, Lydia Karmazin-Brelot, Xavier-Frederic Le Goff, Louis Ricard, and Jean-Pierre Djukic
'Hemichelation, a Way to Stabilize Electron-Unsaturated Complexes: The Case of T-Shaped Pd and Pt Metallacycles'
J. Am. Chem. Soc., 135 (2013), 17839-52

Christophe Werle, Sebastian Dohm, Corinne Bailly, Lydia Karmazin, Louis Ricard, Nicolas Sieffert, Michel Pfeffer, Andreas Hansen, Stefan Grimme, and Jean-Pierre Djukic
'Trans-Cis C-Pd-C Rearrangement in Hemichelates'
Dalton Trans., 46 (2017), 8125-37