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[LCOS] Chimie organique synthétique

Head of the research group

Michel MIESCH
Directeur de Recherche au CNRS

Year of creation of the group - 2005

Secretarial and accounting services provided by

Elisabeth VACCARO
email :
vaccaro@unistra.fr
Phone : +33 (0)3 68 85 16 84

Permanent members

  • Michel MIESCH
    Directeur de Recherche au CNRS
    email: m.miesch@unistra.fr
    Phone : +33 (0)3 68 85 17 52
  • Laurence MIESCH
    Chargée de Recherche au CNRS
    email: lmiesch@unistra.fr
    Phone : +33 (0)3 68 85 17 51
* works for several groups

Non-permanent members

PhD students

  • Lucile ANDNA
  • Frédéric BELTRAN

Research topics

  • Development of new methodologies in organic synthesis
  • Synthesis of steroids (phytosterols, neurosteroids, anti-appetizing steroids, etc.)
  • Functional Food Chemistry
  • Total syntheses of therapeutic molecules

Description of the research group

The LCOS offers the possibility of internships (IUT, M1-M2 masters, chemistry schools ...) or to prepare a thesis at the University of Strasbourg. LCOS is recognized for providing excellent training in synthetic organic chemistry.

LCOS offers research training based on preparative organic chemistry. This makes it possible to address a wide variety of research fields and includes the use of conventional analytical techniques (NMR, IR, UV, HPLC, MS, etc.). This implies that the work will never be monolithic but will necessarily include the use of the whole range of the synthetist, both at the documentary and preparatory or analytical level. The thesis is always considered under its double aspect of original scientific work and period of apprenticeship of a profession.

 

List of equiment and instruments

  • An ozonolyseur
  • A station for distillated solvents
  • A flash chromatography
  • A FT-IR spectrophotometer
  • A High Pressure system
  • An HPLC chromatography
  • A Micro-waves system

Recent publications

Clovis Peter, Philippe Geoffroy and Michel Miesch
Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids
Organic Chemistry Frontiers
, 2017, DOI: 10.1039/C7QO00891K

A. Locci, P. Geoffroy, M. Miesch; A-G. Mensah, G. Pinna
Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment
Frontiers in Cellular Neuroscience, 2017, 11, article 208

Frédéric Beltran, Indira Fabre, Ilaria Ciofini, and Laurence Miesch
Direct Spirocyclization from Keto-sulfonamides: An Approach to Azaspiro Compounds
Org. Lett.
, 2017, 19, 5042−5045

Smirnova E, Marquis V, Poirier L, Aubert Y, Zumsteg J, Ménard R, Miesch L, Heitz T.
Jasmonic
Acid Oxidase 2 (JAO2) hydroxylates jasmonic acid and represses basal defense and resistance responses against Botrytis cinerea infection
Mol Plant.
, 2017, doi: 10.1016/j.molp.2017.07.010

I. Lejri, A. Grimm, M. Miesch, P. Geoffroy, A. Eckert, A.G. Mensah-Nyagan
Allopregnanolone and its analog BR 297 rescue neuronal cells from oxidative stress-induced death through bioenergetic improvement
Biochim. Biophys. Acta, 2017, 1863, 631-64

Photo gallery

A small overview of our research group