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Nov 8 2018

Bioconjugate Chem. [LSAMM]

Abstract: A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear p-conjugated Zn(II)-porphyrin dimer linked at each extremity to a GdDOTA-type complex. This agent has shown very promising potential for PDT applications with good singlet oxygen...[more]

Nov 8 2018

Inorg. Chem. [POMAM]

: The electron paramagnetic resonance spectrum of a highly symmetric chromium(III) spin triangle has revealed highly anisotropic and broadened features. These have been analyzed by full Hamiltonian methods, which consider simultaneous distributions of its isotropic and antisymmetric exchange (Dzyaloshinskii−Moriya) interaction parameters. The examination of several broadening models has...[more]

Oct 19 2018

Chemistry : A European Journal [CLAC]

Abstract : Porphyrins are conjugated, stable chromophores with a central core that binds a variety of metal ions and an easily functionalized peripheral framework. By combining the catalytic, electronic or cytotoxic properties of selected transition metal complexes with the binding and electronic properties of porphyrins, enhanced characteristics of the ensemble are generated. This review...[more]

Oct 19 2018

Chem. Commun. [BCB/POMAM]

Summary : Peptides and proteins with N-terminal amino acid sequences NH2-Xxx-Zzz-His (XZH) form well established high affinity CuII-complexes. Key example is Asp-Ala-His in serum albumin, a Cu-transporter in the blood. This opens a straightforward way to add a high affinity CuII-binding site to almost any peptide or protein, by chemical or recombinant approaches. These motif has been used to...[more]

Oct 15 2018

« Étonnant vivant ! »

Depuis 2O ans, la biologie vit un tournant majeur par le développement technologique, l‘approche pluridisciplinaire et les découvertes engendrées.  La délégation Alsace du CNRS à l’occasion de la fête de la science (édition 2018) a donc célébré le vivant en mobilisant 17 laboratoires strasbourgeois et en accueillant près de 900 élèves (du primaire à la terminale) au Palais universitaire le 12...[more]

Oct 15 2018

Catalysis Communication [SOCAT]

Abstract : Two chiral diphosphites, (S,S)-5,17-bis(1,1′-binaphthyl-2,2′-dioxyphosphanyloxy)-25,26,27,28-tetrapropyloxycalix[4]arene (1) and (S,S)-5,11-bis(1,1′-binaphthyl-2,2′-dioxyphosphanyloxy)-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arene (2), each based on a conical cavity, were synthesised and assessed in the rhodium-catalysed hydroformylation of vinyl...[more]

Oct 11 2018

Structure [IFM]

Abstract : Glycine receptors (GlyR) are pentameric ligand-gated ion channels (pLGIC) that mediate fast inhibitory neurotransmission in the spinal cord and brain stem by switching between discrete conformational states in response to neurotransmitter binding. GlyR dysfunction is linked to several disorders in human including temporal lobe epilepsy, hyperekplexia, and chronic inflammatory pain....[more]