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Conférence V. Torbeev (ED222)

Le 15 décembre 2017
À 10h30
Amphi 2, Institut Le Bel

Dans le cadre des conférences de l’Ecole Doctorale Sciences Chimiques (ED 222), nous avons le plaisir d’accueillir le Vendredi 15 décembre 2017 Amphi 2, Institut Le Bel à 10h30


Vladimir TORBEEV

Laboratory of Protein Chemistry

ISIS – Strasbourg

 

Chemical protein synthesis to study protein structure and function


Abstract:

Modern peptide ligation chemistries allow for an efficient total chemical synthesis of small and medium size proteins. Chemical strategies are inherently flexible and enable incorporation of unlimited combinations of unnatural amino acids, post-translational modifications and various labels. In combination with biophysical techniques, this approach has strong potential to contribute to better understanding of the challenging problems in protein chemistry and biology. Applications of chemical protein synthesis to dissecting mechanisms of protein misfolding and aggregation, studying structure and function of intrinsically disordered proteins and designing new catalytic proteins will be presented.