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Publications récentes

févr. 6 2018

Chemical Science

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In mitochondria, cytochrome c oxidase (CcO) catalyses the reduction of oxygen (O2) to water by using a heme/copper hetero-binuclear active site. Here we report a highly efficient supramolecular approach for the construction of a water-soluble biomimetic model for the active site of CcO. A tridentate copper(II) complex was fixed onto 5,10,15,20-tetrakis(4-sulfonatophenyl)porphinatoiron(III)...[En savoir plus]

janv. 29 2018

ChemComm

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Porphyrin derivatives are highly relevant to biological processes such as light harvesting and charge separation. Their aromatic electronic structure and their accessible HOMO−LUMO gap render porphyrins highly attractive for the development of opto- and electro-active materials. Due to the often difficult covalent synthesis of multiporphyrins, self-assembly using metal complexation as the driving...[En savoir plus]

janv. 12 2018

ChemBioChem

New paradigm for potency :  The crystal structures of E.coli IspH in complex with (E)-4-mercapto-3-methylbut-2-en-1-yl diphosphate enable us to design IspH ligands with improved binding capacities.  A novel binding feature gave rise to compounds that present a new paradigm for the development of more potent IspH inhibitors.     Réference: Franck Borel, Elodie Barbier, Sergiy Krasutsky,...[En savoir plus]

déc. 13 2017

ChemComm

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Référence: F. Bolze, S. Jenni, A. Sour and V. Heitz Molecular photosensitisers for two-photon photodynamic therapy Chem. Commun., 2017, 53, 12857 (DOI: 10.1039/c7cc06133a)   Contact chercheur: Valérie Heitz, Institut de Chimie de Strasbourg Courriel: v.heitz@unistra.fr[En savoir plus]

déc. 11 2017

Coordination Chemistry Reviews

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Référence: Chantal Daniel and Christophe Gourlaouen Chemical bonding alteration upon electronic excitation in transition metal complexes Coordination Chemistry Reviews, 2017, 344, 131-149 (https://doi.org/10.1016/j.ccr.2016.10.010)   Contact chercheur:Chantal Daniel, Institut de Chimie de StrasbourgCourriel: c.daniel@unistra.fr[En savoir plus]

nov. 17 2017

ChemComm

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Référence: Alice Santoro, Nina Ewa Wezynfeld, Milan Vašak, Wojciech Bal and Peter Faller Cysteine and glutathione trigger the Cu–Zn swap between Cu(II)-amyloid-β4-16 peptide and Zn7-metallothionein-3 Chem. Commun., 2017,53, 11634-11637 (http://dx.doi.org/10.1039/C7CC06802F)   Contact chercheur: Peter Faller, Institut de Chimie de Strasbourg Courriel: pfaller@unistra.fr   [En savoir plus]

nov. 17 2017

ACS Omega

Structural characterization of the amyloid precursor protein transmembrane domain and its gamma-cleavage site Anna Itkin,  Evgeniy S. Salnikov, Christopher Aisenbrey, Jesus Raya, Elise Glattard, Vincent Raussens, Jean-Marie Ruysschaert, Burkhard Bechinger ACS Omega, 2017, 2 (10), pp 6525–6534 (team Membrane biophysics and NMR):   Alzheimer’s disease is the most common form of dementia that...[En savoir plus]