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Publications récentes

juin 10 2022

Chem. Eur. J. [LCC/LCQ]

Abstract: A combined experimental/theoretical study of Ni pincer complexes with a bridgehead pyrimidine-based NHC and arylphosphino side arms revealed unique features about stepwise C–H activation, ethylene insertion into the Ni–H bond of an isolated complex followed by ethyl migration with C–CNHC coupling, and an unprecedented C–P bond activation affording via PPh2 migration a NiII complex...[En savoir plus]

juin 8 2022

Food and Chemical Toxicology [Dermatochimie/LCQ/POMAM]

Abstract: Citronellol, one of the most used fragrance compounds worldwide, is one ingredient of Fragrance Mix II used to assess skin allergy to fragrances in dermatitis patients. Pure citronellol is non-allergenic. Main issue is it autoxidizes when exposed to air becoming then allergenic. The increased skin sensitizing potency of air-exposed citronellol has been attributed to the hydroperoxides...[En savoir plus]

juin 1 2022

Chem. Eur. J. [CBAT] + Cover

Abstract: IspG (also called GcpE) is an oxygen-sensitive [4Fe-4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated target for drug development. It converts 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate (MEcPP) into (E)-4-hydroxy-3-methyl-but-2-enyl-1-diphosphate (HMBPP). The reaction, assimilated to a reductive dehydration, involves redox...[En savoir plus]

juin 1 2022

Molecules [CBAT]

Abstract: The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. The absence of this pathway in mammalians makes it an interesting target for the discovery of novel anti-infectives. As last enzyme of this pathway,...[En savoir plus]

mai 20 2022

Organic Letters [SOPHY]

Abstract: The first synthesis of gem-difluorinated ene–ynamides is presented via deprotonation of trifluoromethylated N-allenamides and δ extrusion of fluorine. These highly reactive building blocks, owing to their dual functional groups, offer a unique entry to difluorinated dienes and to stereodefined, monofluoro-substituted dienes. Stereoselective addition to the ynamide moiety led to...[En savoir plus]

mai 16 2022

J. Org. Chem. [SOPHY]

Abstract: A synthesis of new-to-nature aza-iridoids via ynamides is presented. ZrCl4 proved to be the best acid to perform this transformation. Various ynamides were accommodated, and seco-iridoids could be obtained as well. Aza-iridoids were infiltrated into leaves of Scrophularia Nodosa, an iridoid-producing plant species. High-resolution mass spectrometry coupled to computational metabolomic...[En savoir plus]

mai 9 2022

Actualités de l’INC [Biophysique des membranes et RMN]

L’Institut de Chimie de Strasbourg a le plaisir de vous annoncer que l’article « Inorganic phosphate in growing calcium carbonate abalone shell suggests a shared mineral ancestral precursor » récemment publié dans Nature Communication, auquel Philippe Bertani (équipe Biophysique des membranes et RMN, Institut de Chimie de Strasbourg, UMR 7177) a collaboré, vient de faire l’objet d’une...[En savoir plus]

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