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Publications récentes

mars 31 2020

Chem. Comm. [BCB]

Abstract : The measurement of exchangeable Cu2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb3+ luminescent turn-off sensor for Cu2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu2+ detection in the presence of a biological fluorescent background. Graphical...[En savoir plus]

mars 26 2020

Chemistry Eur. J. [LCSOM]

Abstract : The pentamethylcyclopentadienyl N‐heterocyclic carbene nickel complex [Ni(η 5 ‐C 5 Me 5 )Cl(IMes)] (IMes = 1,3‐dimesitylimidazol‐2‐ylidene) efficiently catalyses the anti‐Markovnikov hydroboration of alkenes with catecholborane in the presence of a catalytic amount of potassium tert ‐butoxide, and joins the very exclusive club of nickel catalysts for this important transformation....[En savoir plus]

mars 23 2020

Int. J. of Quantum Chemistry [LCQ]

Abstract : Two (so‐called left and right) variants of N‐centered ensemble density‐functional theory (DFT) are presented. Unlike the original formulation of the theory, these variants allow for the description of systems with a fractional electron number. While conventional DFT for open systems uses only the true electron density as basic variable, left/right N‐centered ensemble DFT relies...[En savoir plus]

mars 3 2020

Angew. Chem. Int. Ed. [BCB]

Abstract: Copper-complexes are of medicinal and biological interest, including as anticancer drugs designed to cleave intracellular biomolecules via O2 activation. To exhibit such activity, the copper complex must be redox-active and resistant to dissociation. Metallothioneins (MTs) and glutathione (GSH) are abundant in the cytosol and nucleus. Because they also are thiol-rich reducing molecules...[En savoir plus]

janv. 21 2020

Chemistry Eur. J. [CBAT/RMN]

Abstract: IspH/LytB, an oxygen‐sensitive [4Fe‐4S] enzyme, catalyzes the last step of the methylerythritol phosphate (MEP) pathway, a target for the development of new antimicrobial agents. This metalloenzyme converts (E)‐4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl diphosphate (HMBPP) into the two isoprenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Here, the synthesis...[En savoir plus]

janv. 13 2020

J. Mat. Chem. C [LECPCS]

Abstract: A series of three new polyoxometalate/spiromolecule compounds – including the (TBA)3[AlMo6-SN] (SN = spironaphthoxazine) and (TBA)3[AlMo6-SP] (SP = spiropyran) Anderson-type polyoxometalates (POMs) and the unprecedented (TBA)5[P2W15V3-SP] Dawson-type species – has been synthesized and characterized using a full panel of techniques. These hybrids have been thoroughly investigated by...[En savoir plus]

déc. 19 2019

Chemistry Eur. J. [BCB /POMAM]

Abstract: Mounting evidence supports the role of amyloidogenesis, oxidative stress, and metal dyshomeostasis in the development of neurodegenerative disorders. Parkinson's Disease is characterized by α-Synuclein (αSyn) accumulation and aggregation in brain regions, also promoted by Cu2+. αSyn is modified by reactive carbonyl species, including acrolein (ACR). Notwithstanding these findings, the...[En savoir plus]