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Publications récentes

déc. 6 2018

Chemistry : A European Journal [ECMC, SOCAT, LCSOM]

Abstract : A new way of introducing a N-heterocyclic carbene cap onto cyclodextrins has been devised. The benzimidazolium intermediates were found to behave as receptors towards cavity matching anions. The corresponding C1- and C2-symmetrical regioisomeric carbene gold(I) complexes have been tested in a benchmark asymmetric cycloisomerization of 1,6-enynes. Up to 50% ee was achieved for the...[En savoir plus]

nov. 15 2018

Chem. Commun. [BCB]

Summary : Copper and zinc trafficking in and around cells, mainly between proteins, is a very fundamental and essential process in most living organisms and impairment of such trafficking can be lethal, like well documented in the genetic Cu-overload Wilson  diseases. Moreover, the metabolism of these essential metal ions Cu and Zn are connected (e.g. Wilsons disease can be treated by Zn...[En savoir plus]

nov. 8 2018

Bioconjugate Chem. [LSAMM]

Abstract: A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear p-conjugated Zn(II)-porphyrin dimer linked at each extremity to a GdDOTA-type complex. This agent has shown very promising potential for PDT applications with good singlet oxygen...[En savoir plus]

nov. 8 2018

Inorg. Chem. [POMAM]

Synopsis
: The electron paramagnetic resonance spectrum of a highly symmetric chromium(III) spin triangle has revealed highly anisotropic and broadened features. These have been analyzed by full Hamiltonian methods, which consider simultaneous distributions of its isotropic and antisymmetric exchange (Dzyaloshinskii−Moriya) interaction parameters. The examination of several broadening models has...[En savoir plus]

oct. 19 2018

Chemistry : A European Journal [CLAC]

Abstract : Porphyrins are conjugated, stable chromophores with a central core that binds a variety of metal ions and an easily functionalized peripheral framework. By combining the catalytic, electronic or cytotoxic properties of selected transition metal complexes with the binding and electronic properties of porphyrins, enhanced characteristics of the ensemble are generated. This review...[En savoir plus]

oct. 19 2018

Chem. Commun. [BCB/POMAM]

Summary : Peptides and proteins with N-terminal amino acid sequences NH2-Xxx-Zzz-His (XZH) form well established high affinity CuII-complexes. Key example is Asp-Ala-His in serum albumin, a Cu-transporter in the blood. This opens a straightforward way to add a high affinity CuII-binding site to almost any peptide or protein, by chemical or recombinant approaches. These motif has been used to...[En savoir plus]

oct. 15 2018

Catalysis Communication [SOCAT]

Abstract : Two chiral diphosphites, (S,S)-5,17-bis(1,1′-binaphthyl-2,2′-dioxyphosphanyloxy)-25,26,27,28-tetrapropyloxycalix[4]arene (1) and (S,S)-5,11-bis(1,1′-binaphthyl-2,2′-dioxyphosphanyloxy)-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arene (2), each based on a conical cavity, were synthesised and assessed in the rhodium-catalysed hydroformylation of vinyl...[En savoir plus]