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Actualités de l'institut

sept. 20 2018

J. Phys. Chem. Lett. [LCQ]

Abstract : Whereas third row transition metal carbonyl α-diimine complexes display luminescent properties and possess low-lying triplet metal-to-ligand charge transfer (MLCT) states efficiently accessible by a spin–vibronic mechanism, first row analogues hold low-lying metal-centered (MC) excited states that could quench these properties. Upon visible irradiation, different functions are...[En savoir plus]

sept. 20 2018

Soutenance de thèse de Justine Wolf

Soutenance de thèse de doctorat de Justine Wolf Jeudi 20 Septembre 2018 à 14h00, Amphi Fischer (Institut de Chimie). Titre : "Biophysical investigation of the LAH4 family peptide"   Directeurs de thèse: Burkhard Bechinger, Biophysique des Membranes et RMN, Institut de Chimie de Strasbourg (UMR 7177) et Régine Süss.[En savoir plus]

sept. 19 2018

Chemistry : A European Journal [LCSOM]

Abstract : The reaction of H₃SiR (R=Ph, nBu) with a cationic Cp*‐and benzo[h]quinolinyl‐ based iridacycle [1b]+ gives rise to new [(Ir‐H)→SiRH₂]+ adducts. In the presence of tetrahydrofuran (THF) the latter adducts readily convert by H₂ gas elimination at subambient temperature into new THF‐stabilized metallacyclic Ir(III)‐“silylene” complexes that were characterized in situ by NMR spectroscopic...[En savoir plus]

sept. 19 2018

BBA - Biomembranes [Biophysique des membranes et RMN]

Abstract : γ-Secretase is an integral membrane protein complex and is involved in the cleavage of the amyloid precursor protein APP to produce amyloid-β peptides. Amyloid-β peptides are considered causative agents for Alzheimer's disease and drugs targeted at γ-secretase are investigated as therapeutic treatments. We synthesized new carprofen derivatives, which showed γ-secretase modulating...[En savoir plus]

sept. 19 2018

Soutenance de thèse de Killian Deur

Soutenance de thèse de doctorat de Killian Deur Mercredi 19 Septembre 2018 à 13h30, Collège Doctoral Européen (salle du RDC). Titre : "Excited states in ensemble density functional theory: from the Hubard model to the exact Hamiltonian with range separation."   Directeur de thèse: Emmanuel Fromager, LCQ, Institut de Chimie.[En savoir plus]

sept. 18 2018

Biophysical J. [Biophysique des membranes et RMN]

Abstract : A synergistic enhancement of activities has been described for the amphipathic cationic antimicrobial peptides magainin 2 and PGLa when tested in antimicrobial assays or in biophysical experiments using model membranes. In the presence of magainin 2, PGLa changes from an in-planar alignment parallel to the membrane surface to a more transmembrane orientation when investigated in...[En savoir plus]

sept. 18 2018

Biophysical J. [Biophysique des membranes et RMN]

Abstract : Apolipoprotein A-I is the major protein component of high-density lipoproteins and fulfils important functions in lipid metabolism. Its structure consists of a chain of tandem domains of amphipathic helices. Using this protein as a template membrane scaffolding protein, class A amphipathic helical peptides were designed to support the amphipathic helix theory and later as therapeutic...[En savoir plus]