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Actualités de l'institut

mai 29 2020

iScience [OMECA]

Summary : Metalloenzymes use earth-abundant non-noble metals to perform high-fidelity transformations in the biological world. To ensure chemical efficiency, metalloenzymes have acquired evolutionary reactivity-enhancing tools. Among these, the entatic state model states that a strongly distorted geometry induced by ligands around a metal center gives rise to an energized structure called...[En savoir plus]

mai 29 2020

Beilstein J. Org. Chem. [OMECA]

Abstract : Copper catalysis finds applications in various synthetic fields by utilizing the ability of copper to sustain mono- and bielectronic elementary steps. Further to the development of well-defined copper complexes with classical ligands such as phosphines and N-heterocyclic carbenes, a new and fast-expanding area of research is exploring the possibility of a complementing metal-centered...[En savoir plus]

mai 28 2020

Chemical Research in Toxicology [Dermatochimie/POMAM]

Abstract : Linalool is one of the most commonly used fragrance terpenes in consumer products. While pure linalool is considered as non-allergenic because it has a very low skin sensitization potential, its autoxidation on air leads to allylic hydroperoxides that have been shown to be major skin sensitizers. These hydroperoxides have the potential to form antigens via radical mechanisms. In order...[En savoir plus]

mai 26 2020

Synthesis [SOPhy]

Abstract : Tertiary enamides display versatile reactivity and great stability compared to their enamine congeners. This review covers progress made in the development of new methods involving the enaminic reactivity of tertiary enamides with respect to the synthesis of complex nitrogen-containing compounds. A focus on the preparation of biologically active molecules is also presented. The...[En savoir plus]

mai 26 2020

Chemistry Eur. J. [IFM]

Summary : Nitro compounds are known to change reaction rates and kinetic concentration dependence of Brønsted‐acid‐catalyzed reactions. Yet, no mechanistic model exists to account for these observations. Herein we present an atomistic model for the catalytically active form for an alcohol dehydroazidation reaction, generated by DFT calculations. which consists of an H‐bonded aggregate of two...[En savoir plus]

mai 14 2020

Bioinformatics [IFM]

Summary : Glycine receptors (GlyR) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. We have collected 218 unique chemical entities with documented modulatory activities at the GlyR and built a database named GRALL. This collection includes agonists, antagonists, positive and negative allosteric modulators and a number of...[En savoir plus]

mai 12 2020

Chemistry Eur. J. [POMAM / LCQ]

Abstract : Previously reported ferromagnetic triangles (NnBu4)2[Cu3(μ‐Cl)2(μ‐4‐NO2‐pz)3Cl3] (1), (PPN)2[Cu3(μ‐Cl)2(μ‐pz)3Cl3](2), (bmim)2[Cu3(μ‐Cl)2(μ‐pz)3Cl3] (3) and newly reported (PPh4)2[Cu3(μ‐Cl)2(μ‐4‐Ph‐pz)3Cl3] (4) were studied by magnetometry, Electron Paramagnetic Resonance (EPR) spectroscopy and ab initio calculations to assess the origins of their ferromagnetism and of the magnetic...[En savoir plus]