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Actualités de l'institut

sept. 19 2018

Chemistry : A European Journal [LCSOM]

Abstract : The reaction of H₃SiR (R=Ph, nBu) with a cationic Cp*‐and benzo[h]quinolinyl‐ based iridacycle [1b]+ gives rise to new [(Ir‐H)→SiRH₂]+ adducts. In the presence of tetrahydrofuran (THF) the latter adducts readily convert by H₂ gas elimination at subambient temperature into new THF‐stabilized metallacyclic Ir(III)‐“silylene” complexes that were characterized in situ by NMR spectroscopic...[En savoir plus]

sept. 19 2018

BBA - Biomembranes [Biophysique des membranes et RMN]

Abstract : γ-Secretase is an integral membrane protein complex and is involved in the cleavage of the amyloid precursor protein APP to produce amyloid-β peptides. Amyloid-β peptides are considered causative agents for Alzheimer's disease and drugs targeted at γ-secretase are investigated as therapeutic treatments. We synthesized new carprofen derivatives, which showed γ-secretase modulating...[En savoir plus]

sept. 19 2018

Soutenance de thèse de Killian Deur

Soutenance de thèse de doctorat de Killian Deur Mercredi 19 Septembre 2018 à 13h30, Collège Doctoral Européen (salle du RDC). Titre : "Excited states in ensemble density functional theory: from the Hubard model to the exact Hamiltonian with range separation."   Directeur de thèse: Emmanuel Fromager, LCQ, Institut de Chimie.[En savoir plus]

sept. 18 2018

Biophysical J. [Biophysique des membranes et RMN]

Abstract : A synergistic enhancement of activities has been described for the amphipathic cationic antimicrobial peptides magainin 2 and PGLa when tested in antimicrobial assays or in biophysical experiments using model membranes. In the presence of magainin 2, PGLa changes from an in-planar alignment parallel to the membrane surface to a more transmembrane orientation when investigated in...[En savoir plus]

sept. 18 2018

Biophysical J. [Biophysique des membranes et RMN]

Abstract : Apolipoprotein A-I is the major protein component of high-density lipoproteins and fulfils important functions in lipid metabolism. Its structure consists of a chain of tandem domains of amphipathic helices. Using this protein as a template membrane scaffolding protein, class A amphipathic helical peptides were designed to support the amphipathic helix theory and later as therapeutic...[En savoir plus]

sept. 17 2018

Soutenance de thèse de Jean-Charles Bruyere

Soutenance de thèse de doctorat de Jean-Charles Bruyere Lundi 17 Septembre 2018 à 15h00, amphithéâtre Alain Beretz au Nouveau Patio. Titre : " Synthèse et étude de complexes organométalliques de zinc(II) and magnesium(II) stabilisés par des ligands de type carbènes N-hétérocycliques "   Directeurs de thèse: Laurent Ruhlmann et Corinne Boudon, LECPCS, Institut de Chimie.[En savoir plus]

sept. 14 2018

Soutenance de thèse de Mary-Ambre Carvalho

Soutenance de thèse de doctorat de Mary-Ambre Carvalho Vendredi 14 Septembre 2018 à 14h00, amphithéâtre du Collège Doctoral Européen. Titre : "Vers la synthèse de nanostructures construites à partir de porphyrines"   Directeur de thèse: Romain Ruppert, CLAC, Institut de Chimie.[En savoir plus]