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Actualités de l'institut

janv. 21 2020

Chemistry Eur. J. [CBAT/RMN]

Abstract: IspH/LytB, an oxygen‐sensitive [4Fe‐4S] enzyme, catalyzes the last step of the methylerythritol phosphate (MEP) pathway, a target for the development of new antimicrobial agents. This metalloenzyme converts (E)‐4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl diphosphate (HMBPP) into the two isoprenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Here, the synthesis...[En savoir plus]

janv. 13 2020

J. Mat. Chem. C [LECPCS]

Abstract: A series of three new polyoxometalate/spiromolecule compounds – including the (TBA)3[AlMo6-SN] (SN = spironaphthoxazine) and (TBA)3[AlMo6-SP] (SP = spiropyran) Anderson-type polyoxometalates (POMs) and the unprecedented (TBA)5[P2W15V3-SP] Dawson-type species – has been synthesized and characterized using a full panel of techniques. These hybrids have been thoroughly investigated by...[En savoir plus]

déc. 19 2019

Chemistry Eur. J. [BCB /POMAM]

Abstract: Mounting evidence supports the role of amyloidogenesis, oxidative stress, and metal dyshomeostasis in the development of neurodegenerative disorders. Parkinson's Disease is characterized by α-Synuclein (αSyn) accumulation and aggregation in brain regions, also promoted by Cu2+. αSyn is modified by reactive carbonyl species, including acrolein (ACR). Notwithstanding these findings, the...[En savoir plus]

déc. 19 2019

Organic Geochemistry [Biogéochimie moléculaire]

Abstract: The widely distributed aromatic di- and triterpenoids from higher plants occurring in sediments are formed by diagenetic microbial processes affecting their precursor plant lipids. These compounds and their stable isotopic composition (δ13C and δ2H) have the potential to be used for palaeoenvironmental and palaeoclimatic studies. In the present study, the isotopic composition of di-...[En savoir plus]

déc. 19 2019

Organic Geochemistry [Biogéochimie moléculaire]

Abstract: Birch bark tar, an organic material frequently encountered during archaeological excavations, has been identified from its lipid composition on the cracks of a ceramic dated to the late Neolithic. Lipids of this black substance were dominated by a characteristic triterpenoid assemblage of lupane-related triterpenoids from birch bark, together with their thermal degradation products...[En savoir plus]

déc. 16 2019

Soutenance de thèse d'Alice Santoro

Soutenance de thèse de doctorat d'Alice Santoro Lundi 16 Décembre 2019 à 14h00, Amphithéâtre du Collège Doctoral Européen. Titre : “Impact of Cu-binding and reducing biomolecules on the redox activity and stability of medicinal-relevant Cu-complexes. Case studies of Cu-Amyloid β species and Cu-based drugs.”  Directeur de thèse: Prof. P. Faller, équipe BCB, Institut de Chimie (UMR 7177).[En savoir plus]

déc. 13 2019

Inorganica Chimica Acta [POMAM]

Abstract : Mononuclear chromium(III) complexes of formula mer-[CrIIICl3(pz*H)3] (pz*H = pyrazole (pzH), and substituted pyrazoles: 3-Me-pzH, 4-Me-pzH, 4-Cl-pzH, 4-Br-pzH, 4-I-pzH) and trans-[CrIIICl2(pzH)4]Cl were synthesized from reactions of CrCl3 hydrate and pyrazole ligands and crystallographically characterized. The fluxional behavior of the complexes, attributed to pyrazole...[En savoir plus]