Percée décisive dans le domaine de l’hydroformylation asymétrique

Metal confinement can make the difference, as shown by M. Jouffroy et al. in a recent Communication in Angew. Chem. . The use of cyclodextrin derivatives with an introverted PIII donor atom in the rhodium-catalyzed hydroformylation of styrene leads to high iso- and enantioselectivity. This is due to the selective formation of monophosphane complexes in which the cyclodextrin cavity tightly wraps around the metal center, like Russian nesting dolls. For more information see M. Jouffroy, R. Gramage-Doria, D. Armspach, D. Sémeril, W. Oberhauser, D. Matt; L. Toupet, Angew. Chem. (2014)  DOI: 10.1002/anie.201311291