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Organic & Biomolecular Chemistry [SOPhy]

mai 29 2019

Abstract :

An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described.  Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at room temperature. Likewise, terminal alkynes react with sulfonylamides to provide enesulfonamides. Z/E enesulfonamides can be transformed exclusively into E enesulfonamides.

Graphical abstract:


Reference :

Lucile Andna and Laurence Miesch
Metal-free synthesis of activated ynesulfonamides and tertiary enesulfonamides

The article was first published on 20 May 2019
Org. Biomol. Chem., 2019, Advance Article - DOI: https://doi.org/10.1039/C9OB00947G

Contact chercheur :

Laurence Miesch, équipe SOPhy, Institut de Chimie, UMR 7177.