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janv. 12 2018

New paradigm for potency :  The crystal structures of E.coli IspH in complex with (E)-4-mercapto-3-methylbut-2-en-1-yl diphosphate enable us to design IspH ligands with improved binding capacities.  A novel binding feature gave rise to compounds that present a new paradigm for the development of more potent IspH inhibitors.




Franck Borel, Elodie Barbier, Sergiy Krasutsky, Karnjapan Janthawornpong, Philippe Chaignon, C. Dale Poulter, Jean-Luc Ferrer, and Myriam Seemann

Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials

ChemBioChem 2017,18, 2137 – 2144, doi:10.1002/cbic.201700363


Contact chercheur:

Myriam Seemann, Institut de Chimie de Strasbourg

Courriel: mseemann@unistra.fr